Abstract
To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups: one control group and 3 treatment groups (cell therapy and gene cell therapy). Echocardiography reviews were performed on three occasions and histopathological analysis was performed after 4 weeks. Analysis of variance (ANOVA), Tukey and Wilcoxon tests, were performed. Association of vascular endothelial growth factor (VEGF) with angiopoietin1 (Ang1) presented satisfactory results in the improvement of ventricular function following ischemic cardiomyopathy in mini pigs when compared to the results of the other treated groups. The therapy with VEGF and the combination of VEGF with Ang1, promoted recovered function of the myocardium, characterized by reduced akinetic area and induction of neovascularization.
References
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J K ChaeG Y Koh
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·J ChenM Chopp
Feb 27, 2004·Cardiovascular Research·Alexander BabiakJohannes Waltenberger
Mar 16, 2004·Lancet·P Richard VullietMark D Kittleson
Nov 1, 2005·Journal of the American College of Cardiology·Bodo E StrauerMatthias Köstering
Dec 13, 2005·Circulation Research·Thomas Eschenhagen, Wolfram H Zimmermann
Oct 16, 2007·European Heart Journal·Christian ValinaEckhard Alt
Apr 9, 2010·Molecular Biology of the Cell·Patricia A Zuk
Aug 17, 2010·PloS One·Maria E DanovizJose E Krieger
May 21, 2011·British Medical Bulletin·Abdul M MozidAnthony Mathur
Sep 22, 2011·Clinical Pharmacology and Therapeutics·M S PennM E Mayorga
Apr 28, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Oren GordonEli Keshet
Jun 12, 2013·Cell Stem Cell·Jessica C Garbern, Richard T Lee
Mar 1, 2014·Acta Biomaterialia·Dan KaiSeeram Ramakrishna
Mar 7, 2014·Antioxidants & Redox Signaling·Polina GoichbergAnnarosa Leri