Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma

Cancer
Naoyo NishidaMasamichi Kojiro

Abstract

The vascular endothelial growth factor (VEGF) family and VEGF receptors (VEGFR) play an essential role in the angiogenesis of both pathologic and nonpathologic conditions. However, the prognostic significance of VEGF and VEGFR expression in ovarian carcinoma is unclear. The tissue expression levels of VEGF-A, VEGF-C, VEGFR-2, and VEGFR-3 in 80 specimens of ovarian carcinoma were examined immnohistochemically. The results obtained were analyzed clinicopathologically. VEGF-A, VEGF-C, VEGFR-2, and VEGFR-3 were expressed both in tumor cells and in adjacent endothelial cells of blood and lymph vessels. The tissue expressions of VEGF-C and VEGFR-2 were correlated significantly with tumor extension, including peritoneal metastases outside the pelvic cavity (P = 0.0010 and P = 0.0008, respectively), lymph node metastases (P = 0.0030 and P = 0.0018, respectively), and positive ascitic cytology (P = 0.025 and P = 0.0016, respectively). Conversely, there was no significant correlation between VEGF-A and VEGFR-3 expression and clinicopathologic features of ovarian carcinoma. Logistic regression analysis revealed that the expressions of VEGF-C and VEGFR-2 also were independent risk factors for peritoneal and lymph node metastases. Survival ...Continue Reading

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jul 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G A OmuraR C Park
Jan 1, 1989·Current Topics in Pathology. Ergebnisse Der Pathologie·S G Silverberg
Jun 1, 1984·American Journal of Obstetrics and Gynecology·G D MalkasianM H Greene
Apr 5, 1995·Journal of the National Cancer Institute·C A BoocockS K Smith
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·M OrlandiniS Oliviero
Aug 15, 1997·Cancer·T KakuH Nakano
Oct 10, 1997·American Journal of Obstetrics and Gynecology·O AbulafiaD M Sherer
Oct 8, 1998·Cancer·T KakuH Nakano
Nov 7, 1999·Japanese Journal of Cancer Research : Gann·J KurebayashiH Sonoo
Mar 29, 2000·CA: a Cancer Journal for Clinicians·R T GreenleeP A Wingo
Mar 30, 2000·International Journal of Cancer. Journal International Du Cancer·T AndréE Chastre
Nov 1, 2001·Neoplasia : an International Journal for Oncology Research·M L GeorgeR I Swift
Jul 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T AmiokaK Chayama
Feb 4, 2003·Nature Medicine·Shahin Rafii, Mihaela Skobe

❮ Previous
Next ❯

Citations

Dec 17, 2008·International Journal of Colorectal Disease·Andrew A AlabiJohn Greenman
Jun 26, 2012·Cancer Metastasis Reviews·Rémi LonguespéeMichel Salzet
Sep 25, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·César Gómez-RaposoAndrés Redondo
Oct 24, 2013·Environmental Toxicology and Pharmacology·Kalimuthu SenthilkumarSe-Kwon Kim
Dec 4, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hanna SallinenSeppo Yla-Herttuala
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Mar 1, 2007·Vascular Health and Risk Management·Naoyo NishidaMasamichi Kojiro
Jan 25, 2013·International Journal of Molecular Sciences·Jui-Chieh ChenJen-Liang Su
Jan 9, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Soo Jung LeeWansik Yu
Jun 15, 2007·Acta Oncologica·Pia P VihinenSeppo O Pyrhönen
Apr 7, 2009·Leukemia & Lymphoma·Semra PaydasSinan Yavuz
Mar 11, 2005·Expert Review of Anticancer Therapy·Christopher F Nicodemus, Jonathan S Berek
Oct 20, 2007·Expert Review of Anticancer Therapy·Ernest S Han, Bradley J Monk
Mar 12, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Bin LiangChuan Liu
May 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Siddapuram SivaprasadDuvvuru Nageshwar Reddy
Apr 25, 2012·Critical Reviews in Oncology/hematology·Arne R M van der BiltAnna K L Reyners
May 28, 2014·Neoplasia : an International Journal for Oncology Research·Jaeyoung J LimRonald J Buckanovich
Oct 18, 2008·Magnetic Resonance Imaging Clinics of North America·Isabelle Thomassin-NaggaraMarc Bazot
Mar 18, 2008·Critical Reviews in Oncology/hematology·Phuong DinhAhmad Awada
Apr 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kirsi A SuhonenVeli-Matti Kosma
Aug 14, 2012·Gastroenterology Research and Practice·Evgenia HalkiaPaul Sugarbaker
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Ifat SherBrenda L Coomber
Jun 4, 2008·Annals of the New York Academy of Sciences·Marc G Achen, Steven A Stacker
Dec 6, 2008·International Journal of Cancer. Journal International Du Cancer·Whitney A SpannuthAnil K Sood
Feb 18, 2012·International Journal of Cancer. Journal International Du Cancer·Minna SopoSeppo Yla-Herttuala
Feb 25, 2006·Journal of Biotechnology·Wilko Thiele, Jonathan P Sleeman
Jul 24, 2010·The American Journal of Pathology·Ernst Lengyel
Jul 10, 2012·Gynecologic Oncology·Marek CybulskiMagdalena Mazurek-Kociubowska
Feb 11, 2014·The American Journal of Pathology·Alessandra DecioDorina Belotti
Feb 16, 2005·Cancer Cell·Marc G AchenSteven A Stacker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.