Vascular endothelial growth factor C complements the ability of positron emission tomography to predict nodal disease in lung cancer

The Journal of Thoracic and Cardiovascular Surgery
Farhood FarjahMichael S Mulligan

Abstract

Vascular endothelial growth factors (VEGFs) C and D are biologically rational markers of nodal disease that could improve the accuracy of lung cancer staging. We hypothesized that these biomarkers would improve the ability of positron emission tomography (PET) to predict nodal disease among patients with suspected or confirmed non-small cell lung cancer (NSCLC). A cross-sectional study (2010-2013) was performed of patients prospectively enrolled in a lung nodule biorepository, staged by computed tomography (CT) and PET, and who underwent pathologic nodal evaluation. Enzyme-linked immunosorbent assay was used to measure biomarker levels in plasma from blood drawn before anesthesia. Likelihood ratio testing was used to compare the following logistic regression prediction models: ModelPET, ModelPET/VEGF-C, ModelPET/VEGF-D, and ModelPET/VEGF-C/VEGF-D. To account for 5 planned pairwise comparisons, P values <.01 were considered significant. Among 62 patients (median age, 67 years; 48% men; 87% white; and 84% NSCLC), 58% had fluorodeoxyglucose uptake in hilar and/or mediastinal lymph nodes. The prevalence of pathologically confirmed lymph node metastases was 40%. Comparisons of prediction models revealed the following: ModelPET/VEGF-...Continue Reading

References

Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·George F ReedBruce D Meade
Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bernard J ParkValerie W Rusch
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rosalie C VineyMichael J Fulham
Jan 1, 1950·Cancer·W J YOUDEN
Dec 16, 2005·Nature·Kari AlitaloTatiana V Petrova
Mar 29, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerarda J M HerderUNKNOWN POORT Study Group
Sep 26, 2006·The Annals of Thoracic Surgery·Anthony LemaireWilliam R Burfeind
Dec 22, 2006·American Journal of Epidemiology·Eric Vittinghoff, Charles E McCulloch
Jul 3, 2009·The New England Journal of Medicine·Barbara FischerLiselotte Højgaard
Jan 18, 2014·Respiration; International Review of Thoracic Diseases·M B von BartheldJ T Annema
Apr 1, 2014·Journal of the National Cancer Institute·Margaret S PepeChristopher I Li
Oct 11, 2014·The Annals of Thoracic Surgery·Shaun DalyJeffrey A Borgia
Nov 30, 2014·Journal of the National Cancer Institute·Michael J PencinaEwout W Steyerberg

❮ Previous
Next ❯

Citations

Sep 8, 2015·The Journal of Thoracic and Cardiovascular Surgery·Sunil Singhal
Jul 1, 2019·The Annals of Thoracic Surgery·Amelia MaigaEric L Grogan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.