Vascular endothelial growth factor C is an indicator of lymph node metastasis in thoracic esophageal squamous cellcarcinomas and its role in long-term survival after surgery

Thoracic Cancer
Xu-feng PanWen-hu Chen

Abstract

To define the role of vascular endothelial growth factor C (VEGF-C) on lymph node (LN) metastasis of human esophageal squamous cell carcinoma (ESCC), and to investigate its impact on overall survival. Real-time polymerase chain reaction was introduced to quantify the expression of VEGF-CmRNA. One hundred and eight samples (59 tumor tissue and 59 paired normal tissue) were analyzed. VEGF-CmRNA expression was significantly higher in tumor tissues than in normal mucosa (P = 0.02). VEGF-CmRNA expression was significantly higher in LN (+) patients than in LN (-) patients (P = 0.04). VEGF-CmRNA expression was related to a positive LN number (P = 0.06) and a positive LN station number (P = 0.04). VEGF-CmRNA expression was significantly higher in stage III and IV patients than in stage I and II patients (P = 0.03). A logistic regression model showed that VEGF-CmRNA and T status were independent risk factors for LN metastasis(P < 0.05). In univariate analysis, survival tended to be poorer in the VEGF-CmRNA high expression group (22.0 months vs. 44.0 months, P = 0.08). A Cox regression model revealed that a positive LN station number was the only independent risk factor for overall survival (P < 0.01). VEGF-C was a useful indicator for L...Continue Reading

References

May 30, 1997·Science·M JeltschK Alitalo
Jul 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shoji NatsugoeTakashi Aikou
Dec 17, 2004·Pharmacological Reviews·Ann HoebenErnst A De Bruijn
Jun 16, 2005·Journal of Molecular Endocrinology·S A BustinM W Pfaffl
Dec 17, 2005·Advances in Clinical Chemistry·Bernhard Kaltenboeck, Chengming Wang
Jan 19, 2006·Advances in Therapy·Sinan YavuzSeyda Erdogan
Sep 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sudha S Sundar, Trivadi S Ganesan
Feb 19, 2009·The Journal of Pathology·Peng GaoKun Mu
Oct 27, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y P LiuX L Wang
Jun 30, 2010·Journal of Experimental & Clinical Cancer Research : CR·Tatsuya TanakaHiromitsu Takeyama
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Jul 26, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xuemei LiYafang Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.