Vascular endothelial growth factor expression in serous ovarian carcinoma: relationship with topoisomerase II alpha and prognosis

Gynecologic Oncology
Hermann Brustmann

Abstract

This study investigated the expression of vascular endothelial growth factor (VEGF) and topoisomerase II alpha (TPII alpha) in a cohort of serous ovarian carcinomas by immunohistochemistry with regard to outcome and clinicopathologic variables. Formalin-fixed, paraffin-embedded archival tissue sections of 10 benign serous cystadenomas and 41 serous ovarian carcinomas were immunostained with antibodies to VEGF and TPII alpha. Immunostaining for VEGF was scored with regard to quantity and intensity of positively stained cells as weak, focal strong, and diffuse strong. TPII alpha labeling indices (LI) were quantitated as the percentage of positively stained nuclei in 1000 tumor cells. VEGF expression was weak or negative in serous cystadenomas. In contrast, focal or diffuse strong immunostaining was observed in 21 cases (51%) of serous carcinomas. VEGF immunoreactivity was positively related with TPII alpha LI (P = 0.0055), adverse outcome (P = 0.0052), high International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.0158), and high tumor grade (P = 0.0303). TPII alpha LI increased with FIGO stage (P = 0.0076) as well as tumor grade (P = 0.0034) and indicated poor prognosis (P = 0.0182). VEGF immunoreactivity is rela...Continue Reading

References

Jul 25, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M J CostaD Guinee

❮ Previous
Next ❯

Citations

Aug 27, 2013·Archives of Gynecology and Obstetrics·Umran Kucukgoz GulecAytekin Altintas
Jun 19, 2016·Journal of Ovarian Research·Yang BaiXin Lu
Jan 5, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vivian GoodellMary L Disis
May 29, 2008·British Journal of Cancer·G FerrandinaG Scambia
Jan 8, 2009·American Journal of Hematology·Chih-Cheng ChenChing-Fen Yang
Sep 23, 2009·Current Opinion in Obstetrics & Gynecology·Seiji MabuchiTadashi Kimura
Oct 14, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Kirsten M JochumsenOle Mogensen
Mar 1, 2011·Experimental and Therapeutic Medicine·Monica BinaschiCarlo Alberto Maggi
Jun 4, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sohita Dhillon
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Seiji MabuchiMasahide Ohmichi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Farhad KosariGeorge Vasmatzis
Proceedings of the National Academy of Sciences of the United States of America
Charles M PerouDavid Botstein
Proceedings of the National Academy of Sciences of the United States of America
Daniel R RhodesArul M Chinnaiyan
© 2021 Meta ULC. All rights reserved