Vascular endothelial growth factor expression in the basal subtype of breast carcinoma

American Journal of Clinical Pathology
Alfredo Ribeiro-SilvaS Zucoloto

Abstract

The recognition of subtypes of breast carcinomas based on their molecular features has brought new perspectives in breast cancer research. Some key regulators of angiogenesis and tumor infiltration were evaluated in breast carcinomas of basal phenotype (cytokeratin [CK]5+). Immunohistochemical analysis with 14 primary antibodies was performed in 100 formalin-fixed, paraffin-embedded samples of invasive ductal carcinomas. CK5 correlated with indicators of poor outcome, including precocious age, high histologic grade, lymph node positivity, advanced pathologic stage, negativity for hormonal receptors, and a high proliferative rate (Ki-67 labeling index). CK5 also correlated with vascular endothelial growth factor (VEGF) expression but not with the microvessel density. Considering that VEGF-overexpressing neoplastic mammary cells display increased proliferative activity in vitro regardless of the angiogenic effect of VEGF, the differential expression of VEGF might contribute to the more aggressive behavior of these neoplasms. CK5 correlated with tissue inhibitor of metalloproteinase (TIMP)-1, but not matrix metalloproteinase (MMP)-1, MMP-2, extracellular matrix metalloproteinase inducer, TIMP-2 or plasminogen activator inhibitor, ...Continue Reading

References

Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·M WestJ R Nevins
Jan 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peiguo G Chu, Lawrence M Weiss
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Nov 5, 2003·The Journal of Pathology·A BarnesI O Ellis
May 14, 2004·The Journal of Pathology·Dalia M Abd El-RehimIan O Ellis
May 29, 2004·Journal of Clinical Pathology·A NoelJ M Foidart
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Sep 18, 2004·The Journal of Pathology·Paolo ViacavaGeneroso Bevilacqua
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qianren JinAsta Försti
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jarle B ArnesWilliam D Foulkes
Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Manabu AkahaneUnnur P Thorgeirsson
Apr 1, 2006·Diseases of the Colon and Rectum·Fabiana Pirani CarneiroSérgio Zucoloto

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Citations

May 25, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Else MaaeFlemming B Sørensen
Jan 11, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hawa NalwogaLars A Akslen

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