Vascular endothelial growth factor expression levels of gingiva in gingivitis and periodontitis patients with/without diabetes mellitus.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Gonca Cayir KelesHakki Kahraman

Abstract

The aim of this study was to determine vascular endothelial growth factor (VEGF) mRNA expression levels in gingival tissues of gingivitis and periodontitis patients with diabetes mellitus and those without. The hypothesis tested is that expression of VEGF, considered the effective cytokine in the relationship between diabetes and periodontal disease, is differentially affected in gingivitis and periodontitis patients with or without diabetes mellitus compared to healthy controls. Forty-five subjects were evaluated in five groups; individuals with gingivitis (group 1; n = 10), individuals with periodontitis (group 2; n = 10), individuals with gingivitis + type II diabetes (group 3; n = 10), individuals with periodontitis + type II diabetes (group 4; n = 10), and individuals without periodontal and systemic disease (group 5; n = 5). VEGF mRNA levels in gingival tissues were measured by quantitative real-time PCR using Lightcycler. Expression of VEGF mRNA was detected in all groups. There was no significant difference in expression levels of VEGF mRNA between groups (P > 0.05). VEGF expression is probably related to both maintenance of periodontal health and periodontal tissue destruction. It can be concluded that systemic conditi...Continue Reading

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Citations

Sep 12, 2012·Mediators of Inflammation·Gonca Cayir KelesFerda Pamuk
Feb 2, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Giuseppe Alessandro ScardinaPietro Messina
Mar 19, 2014·Journal of Periodontology·Zeynep Pinar KelesGulnur Emingil
Aug 26, 2017·Journal of Oral Microbiology·Daniel BelstrømUlvi Kahraman Gürsoy
Apr 23, 2020·International Journal of Environmental Research and Public Health·Gianna Maria NardiBiagio Rapone
Oct 8, 2019·Journal of Oral Science·Çağla Gül GürkanBurcu Özkan Çetinkaya
Feb 23, 2013·Biomedical Research·Naoki TakizawaKoji Naruishi

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