Vascular endothelial growth factor gene haplotypes in Kawasaki disease

Arthritis and Rheumatism
W B BreunisTaco W Kuijpers

Abstract

To investigate whether common genetic variants in the vascular endothelial growth factor (VEGF) gene are associated with Kawasaki disease (KD) and the subsequent development of coronary artery lesions. Common genetic variants in the VEGF gene were analyzed in an association study in a Dutch cohort of 170 KD patients and 300 healthy Dutch Caucasian controls. Genotyping was done with 5'-nuclease TaqMan assays and 3'-hybridization-triggered fluorescence minor groove binder Eclipse assays. An association with susceptibility to KD was observed with 2 of the 6 single-nucleotide polymorphisms analyzed in VEGF: -2594 A>C (rs699947) and the 236 bp 3' of STP C>T (rs3025039). Also for an 18-bp deletion in the promoter of VEGF a significant difference in the genotype and allele frequencies was observed between the KD patients and the controls. The haplotype CGCC (based on rs699947, rs2010963, rs25648, and rs3025039) was significantly associated with the development of KD (hap score 3.8; P = 0.0002). VEGF plasma levels were significantly higher in patients with the early phase of KD than in the healthy controls, and there was a trend toward higher VEGF plasma levels in KD patients with the -2594 CC and 236 bp 3' of STP CC genotypes. Our res...Continue Reading

References

Dec 1, 1988·The Pediatric Infectious Disease Journal·C L BrosiusD Y Leung
Jan 1, 1997·European Journal of Pediatrics·S MatsuokaY Kuroda
Jun 23, 1998·Lancet·T W KuijpersJ Lam
Mar 11, 1999·The American Journal of Cardiology·M TeraiY Kohno
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Majid ShahbaziPaul N Harden
Jan 16, 2002·American Journal of Human Genetics·Daniel J SchaidGregory A Poland
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Peter KripplHellmut Samonigg
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Aug 11, 2004·Lancet·Jane C Burns, Mary P Glodé
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wesley C ChanRae S M Yeung
Oct 2, 2004·Nature Medicine·Marc E Rothenberg

❮ Previous
Next ❯

Citations

Apr 23, 2013·The Journal of Infection·Nicola PrincipiSusanna Esposito
Jan 23, 2009·Journal of Human Genetics·Akira Hata, Yoshihiro Onouchi
Dec 17, 2010·Journal of Human Genetics·Ho-Chang KuoWei-Chiao Chang
Apr 18, 2009·Carcinogenesis·Rebecca A MasonAngeline S Andrew
Jul 10, 2010·Current Opinion in Rheumatology·Rae S M Yeung
Dec 20, 2007·Pediatric Research·Kazuyuki IkedaToshiro Hara
Feb 5, 2009·Pediatric Research·Yoshihiro Onouchi
Nov 5, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken-Pen WengLuo-Ping Ger
Aug 21, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jan 10, 2009·PLoS Genetics·David BurgnerUNKNOWN International Kawasaki Disease Genetics Consortium
May 22, 2013·PloS One·Fabiola AtzeniCarlo Salvarani
Feb 27, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Sun-Young KongDo-Hoon Lee
Aug 10, 2010·Annual Review of Medicine·Anne H Rowley
Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Nov 23, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Tanja LangsenlehnerUwe Langsenlehner
Aug 29, 2009·Journal of Clinical Gastroenterology·Hung-Chang LeeYann-Jinn Lee
Mar 17, 2009·Journal of Clinical Laboratory Analysis·Shih-Yin ChenFuu-Jen Tsai
Sep 10, 2011·Arthritis and Rheumatism·Willemijn B BreunisUNKNOWN International Kawasaki Disease Genetics Consortium
Jan 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ruhi KapahiNeeti Rajan Singh
Aug 19, 2007·Stroke; a Journal of Cerebral Circulation·Chaeyoung Lee, Minyoung Kong
Mar 23, 2020·Clinical Reviews in Allergy & Immunology·Rajni KumrahSurjit Singh
Jun 29, 2017·European Journal of Pediatrics·S M DietzT W Kuijpers
Dec 5, 2006·Current Opinion in Rheumatology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.