Vascular endothelial growth factor in patients with schizophrenia: A systematic review and meta-analysis

Progress in Neuro-psychopharmacology & Biological Psychiatry
Błażej MisiakAlba Lubeiro

Abstract

Accumulating evidence indicates that schizophrenia might be accompanied by abnormal vascularization. Vascular endothelial growth factor (VEGF) is one of key molecules involved in the development of vessels with vasodilatory activities. We aimed to perform a systematic review and meta-analysis of studies investigating serum or plasma levels of VEGF in patients with schizophrenia and first-episode psychosis (FEP). Electronic databases were searched from their inception until 18th Apr 2018. Meta-analysis was performed using random-effects models with Hedges' g as the effect size estimate. Quality assessment was performed using the Newcastle-Ottawa Scale. We included 15 eligible studies, representing 982 patients and 791 healthy controls. Main analysis revealed no significant differences in VEGF levels between patients and controls (g = 0.10, 95%CI = -0.24-0.45, p = .553). Subgroup analysis demonstrated unaltered levels of VEGF in FEP patients (g = 0.03, 95%CI = -0.53-0.59, p = .911), including antipsychotic-naïve individuals (g = 0.34, 95%CI = -0.07-0.74, p = .103). However, the levels of VEGF were significantly higher in medicated multiple-episode schizophrenia (MES) patients (g = 0.45, 95%CI = 0.03-0.87, p = .036) compared to co...Continue Reading

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Citations

May 23, 2019·European Archives of Psychiatry and Clinical Neuroscience·Isabel MaurusPeter Falkai
Nov 2, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Yasemin Taş TorunElvan İşeri
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May 20, 2020·Translational Psychiatry·André F CarvalhoNathan Herrmann
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Jul 4, 2021·Neuroscience Letters·Antonio RampinoDomenico Ribatti
Dec 9, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Johanna Louise KeelerHubertus Himmerich

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