Vascular Endothelial Growth Factor in Tear Samples of Patients with Systemic Sclerosis

Mediators of Inflammation
Anikó RentkaÁdám Kemény-Beke

Abstract

Systemic sclerosis is an autoimmune disease, characterized by widespread small vessel vasculopathy, immune dysregulation with production of autoantibodies, and progressive fibrosis. Changes in levels of proangiogenic cytokines had already been determined largely in serum. Our aim was to assess the levels of VEGF in human tears of patients with SSC. Forty-three patients (40 female and 3 men, mean (SD) age 61 (48-74) years) with SSc and 27 healthy controls were enrolled in this study. Basal tear sample collection and tear velocity investigations were carried out followed by an ophthalmological examination. Total protein concentrations and VEGF levels were determined in tear samples. The average collected tear fluid volume developed 10.4 μL (1.6-31.2) in patients and 15.63 μL (3.68-34.5) in control subjects. The average total protein level was 6.9 μg/μL (1.8-12.3) in tears of patients and control tears contained an average of 4.132 μg/μL (0.1-14.1) protein. In patients with SSc the average concentration of VEGF was 4.9 pg/μL (3.5-8.1) and 6.15 pg/μL (3.84-12.3) in healthy samples. Total protein production was increased because of the smaller tear volume. Decreased VEGF in tear of SSc patients can be explained also by the decreased...Continue Reading

References

Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Jan 1, 1997·Current Eye Research·M VesaluomaT Tervo
May 7, 2005·AORN Journal·Michelle Byrne
Mar 21, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F BockC Cursiefen
Nov 26, 2008·The Journal of Surgical Research·Philip BaoHarold Brem
Mar 21, 2009·Survey of Ophthalmology·Rajen TailorJeffrey Kwartz
May 8, 2009·The New England Journal of Medicine·Armando GabrielliThomas Krieg
Jan 21, 2010·Clinical Reviews in Allergy & Immunology·Matthias Geyer, Ulf Müller-Ladner
Feb 4, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kaijun LiKaili Wu
Feb 1, 2014·Archives of Medical Science : AMS·Arleta WaszczykowskaPiotr Jurowski

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Citations

Aug 10, 2018·Current Rheumatology Reviews·Victoria A FlowerJohn D Pauling
Jun 12, 2019·Advanced Healthcare Materials·Rosalia MoredduAli K Yetisen
Nov 28, 2019·Physical Review. E·Laura MaguireLoren E Hough
Feb 27, 2021·European Journal of Ophthalmology·Janusz PieczyńskiJolanta Kiewisz
Oct 1, 2021·The Analyst·Yuqi ShiAli K Yetisen

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