Abstract
Hypertrophic cardiomyopathy (HCM) is mostly autosomal dominant disease of the myocardium, which is characterized by myocardial hypertrophy. Vascular endothelial growth factor (VEGF) is involved in myocyte function, growth, and survival. The aim of study was to analyze the clinical significance of VEGF in structural and functional changes in patient with HCM. In a group of 21 patients with nonobstructive HCM, we assessed serum VEGF and analyzed its association with morphological and functional parameters. Compared to healthy controls, serum VEGF was increased: 199 (IQR: 120.4-260.8) ng/L versus 20 (IQR: 14.8-37.7) ng/L, P < 0.001. VEGF levels were associated with left atrium diameter (r = 0.51, P = 0.01), left ventricle ejection fraction (r = -0.56, P = 0.01), fractional shortening (r = -0.54, P = 0.02), left ventricular mass (r = 0.61, P = 0.03), LV mass index (r = 0.46, P = 0.04), vena cava inferior diameter (r = 0.65, P = 0.01), and peak gradient of tricuspid regurgitation (r = 0.46, P = 0.03). Increased VEGF level is associated with structural and functional parameters in patients with HCM and serves as a potential tool for diagnostic process of these patients.
References
Feb 18, 2004·Circulation·Barry J MaronJay N Cohn
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Makoto OkawaYoshinori Doi
Jul 6, 2006·Circulation·Ingeborg FriehsPedro J del Nido
Mar 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Nobutake ShimojoTakashi Miyauchi
Nov 28, 2007·Clinical Biochemistry·Hiroko MatsuuraShozo Kusachi
Apr 9, 2008·The American Journal of Cardiology·Jarkko MaggaJohanna Kuusisto
Jan 13, 2009·European Heart Journal·Francisco CambroneroGregory Y H Lip
Jan 1, 2010·Clinical Cardiology·Toru KuboYoshinori L Doi
Oct 12, 2010·Cardiovascular Research·Elisabeth KazaIngeborg Friehs
Nov 15, 2011·Journal of the American College of Cardiology·Bernard J GershUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Dec 17, 2011·PloS One·Anna LeychenkoMichelle L Matter
Sep 26, 2012·Pediatric Research·Jaime AlkonSeema Mital
Nov 23, 2012·Journal of Biochemistry·Masabumi Shibuya
Mar 5, 2013·European Heart Journal·Caroline J CoatsPerry M Elliott
Apr 23, 2013·Journal of the American College of Cardiology·Jeffrey B GeskePaul Sorajja
Apr 30, 2013·Journal of the American College of Cardiology·Toru KuboYoshinori L Doi
Jun 14, 2014·PloS One·Brendan N PutkoUNKNOWN Alberta HEART Investigators
Sep 1, 2014·European Heart Journal·Perry M ElliottHugh Watkins
Feb 26, 2015·European Heart Journal Cardiovascular Imaging·Roberto M LangJens-Uwe Voigt
Oct 28, 2015·BioMed Research International·Catarina Roma-RodriguesAlexandra R Fernandes