Vascular endothelial growth factor is implicated in early invasion in cervical cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
J KodamaT Kudo


The association between the expression of vascular endothelial growth factor (VEGF) and clinicopathological factors has scarcely been examined in cervical cancer. This study examines the level of VEGF messenger RNA (mRNA) expression in invasive cervical cancer and its association with clinicopathological features including microvessel density. The level of VEGF mRNA was assessed by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) using beta-actin as an internal control in 66 patients with stages Ia-IVb invasive cervical cancer. In 42 patients who underwent surgery, the microvessel count was also assessed by immunostaining for factor VIII-related antigen in the most neovascularised area of the specimen. The highest level of VEGF mRNA expression was observed in early invasive cervical cancers. Except for stage IVb, the stage of the disease inversely correlated with the level of VEGF mRNA (P < 0.05). There was no significant difference in the level of VEGF mRNA with respect to histological cell types. 38 patients with stages Ib-IIb cervical cancer underwent radical hysterectomy and pelvic lymphadenectomy. There was no significant difference in the level of VEGF mRNA with respect to lymph node metastasis, ...Continue Reading


Jul 1, 1992·European Journal of Pediatrics·L Schweigerer, T Fotsis
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Mar 1, 1995·Gynecologic Oncology·D L WigginsP Calabresi
Oct 1, 1995·Gynecologic Oncology·K SchlengerA Lambert
Nov 1, 1993·The Journal of Experimental Zoology·M C AlliegroB M Glaser
Mar 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J KodamaT Kudo
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·G GaspariniP Bevilacqua
Jan 1, 1996·American Journal of Obstetrics and Gynecology·G L BremerJ W Arends
Apr 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·J L RutgersM P Vargas
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·A SekiT Kudo
Feb 28, 1998·Gynecologic Oncology·K TokumoT Kudo
Mar 21, 1998·American Journal of Obstetrics and Gynecology·A ObermairG Gitsch

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