PMID: 11899958Mar 20, 2002Paper

Vascular endothelial growth factor-mediated, endothelium-dependent relaxation in human internal mammary artery

The Annals of Thoracic Surgery
Ming-Hui LiuGuo-Wei He

Abstract

Vascular endothelial growth factor (VEGF) has been shown to have potential to treat ischemic diseases. Moreover, its vasorelaxing or vasodilatory effect might be favorable for relieving graft spasm. In this study, we examined the vasorelaxing effects of recombinant VEGF in isolated human internal mammary artery (IMA) and compared the responses to acetylcholine and nitroglycerin. Isometric tension of IMA ring segments was measured with an organ bath technique. With an optimal resting tension determined from its individual length-tension curve, precontraction was induced by 10(-8) M U46619 and cumulative concentration-relaxation was measured by application of VEGF (10(-12) to 10(-15) M), acetylcholine (10(-10) to 10(-5) M), and then nitroglycerin (10(-4.5) M). Vascular endothelial growth factor induced concentration-dependent relaxation (EC50: -9.89+/-0.05 log M; Emax: 63.2%+/-7.3%) in IMA with intact endothelium. The relaxant responses to VEGF were significantly attenuated by pretreatment with Nomega-nitro-L-arginine (L-NNA) alone and indomethacin + L-NNA, and totally abolished by removal of the endothelium or pretreatment with indomethacin + L-NNA + oxyhemoglobin. Internal mammary arteries became more sensitive to VEGF in the p...Continue Reading

References

Aug 1, 1987·The Annals of Thoracic Surgery·M R SarabuG E Reed
Apr 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·G W He, C Q Yang

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Citations

Mar 16, 2012·Clinical Ophthalmology·Ahmad M MansourUNKNOWN Collaborative Anti-VEGF Ocular Vascular Complications Group
Aug 13, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Ismihan Selen OnanIlhan Sanisoglu
Jun 4, 2010·European Journal of Pharmacology·Rosa María PagánAna Cristina Martínez
Dec 6, 2006·Annals of the New York Academy of Sciences·Eugene W M Ng, Anthony P Adamis
Dec 31, 2009·Acta Ophthalmologica·Ahmad M MansourSivakami A Pai
Jun 21, 2016·The Annals of Thoracic Surgery·Guo-Wei He, David P Taggart
Oct 6, 2010·Human & Experimental Toxicology·Kazim HusainJainarine Lalla
Jul 12, 2007·Human & Experimental Toxicology·Kazim HusainJainarine Lalla
May 9, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth R JacobsMeetha Medhora
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dallit MannheimAmir Lerman
Dec 3, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Homa AshrafpourCho Y Pang
May 1, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Kyung-Ju LeeMin-Jeong Oh
Aug 28, 2007·Molecular and Cellular Biochemistry·Kazim HusainJainarine Lalla
Dec 13, 2006·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Mark S Hughes, Delia N Sang

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