Abstract
Vascular endothelial growth factor (VEGF) increases microvascular permeability and stimulates endothelial cell growth. p53 Overexpression has been associated with resistance to cisplatin-based chemotherapy in patients (pts) with NSCLC. The aim of this study was to evaluate the predictive role of VEGF for chemotherapy response, its relationship with p53, Rb, Bcl-2 and hemoglobin levels and its impact on overall survival in pts with advanced NSCLC. Bronchial or fine-needle biopsy specimens from 85 pts with NSCLC obtained before chemotherapy were analyzed using an immunohistochemical method for VEGF, p53, Rb and Bcl-2. There were 73 males and 12 females with a median age of 62.6 years. The majority of pts (48%) had squamous cell histology. Ten pts had stage IIIA, 25 stage IIIB and 50 stage IV. Thirty six (43%) pts had positive immunostaining for VEGF, 37 (44%) had positive p53, 53 (62%) had negative Rb and 4 (5%) had positive Bcl-2. VEGF was negatively correlated with Rb (r(s) = 0.26; P = 0.015), positively with Bcl-2 (r(s) = 0.22; P = 0.42), whereas no statistically significant correlation with p53, age, stage and histological type was found. In a logistic regression model, adjusting for treatment, VEGF expression was not associa...Continue Reading
References
Oct 29, 1992·Nature·D ShweikiE Keshet
Nov 15, 1990·International Journal of Cancer. Journal International Du Cancer·J BártekD P Lane
Jan 1, 1981·Cancer·A B MillerA Winkler
Nov 15, 1994·International Journal of Cancer. Journal International Du Cancer·K H PlateW Risau
Jun 15, 1995·Nature·D MukhopadhyayV P Sukhatme
Aug 16, 1995·Journal of the National Cancer Institute·R M ElledgeN Robert
Feb 1, 1995·The Journal of Clinical Investigation·A HartmannS S Sommer
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FontaniniG Bevilacqua
Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·T SoussiB Schlichtholz
Jan 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M HöckelP Vaupel
Feb 20, 1997·International Journal of Cancer. Journal International Du Cancer·M VolmJ Mattern
Jun 1, 1997·Chest·C F Mountain
Nov 15, 1997·Journal of the National Cancer Institute·J AlbanellE Dmitrovsky
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FontaniniG Bevilacqua
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M KawasakiN Hara
Jan 16, 1999·Journal of the National Cancer Institute·S AmbsC C Harris
Apr 6, 2000·The Annals of Thoracic Surgery·T A D'AmicoD H Harpole
Apr 26, 2000·British Journal of Cancer·K J O'ByrneA L Harris
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Jun 20, 2001·Thorax·G CoxK J O'Byrne
Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M LiaoD Zhu
Sep 15, 2001·British Journal of Cancer·A GiatromanolakiA L Harris
Oct 10, 2001·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J DunstG Haensgen
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K J O'ByrneJ L Jones
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ang YuanPan-Chyr Yang
Apr 5, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A ImdahlC Ihling
Dec 25, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vanesa GregorcMaurizio Tonato
May 20, 2003·The Journal of Pathology·Alexandra GiatromanolakiAdrian L Harris
Dec 4, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vanesa GregorcMaurizio Tonato
Aug 30, 2005·Oncology·M OggionniF Zunino
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christophe GinestierFrançois Bertucci
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Koji ArakiDaqing Li
Apr 27, 2012·Hepato-gastroenterology·Yong ZhaJing Tan
Citations
Mar 30, 2010·Pathology Oncology Research : POR·Ahmet BircanAhmet Akkaya
Sep 9, 2008·Archivos de bronconeumología·Esther Barreiro
Aug 29, 2006·Oncogene·C GabelliniG Zupi
Jul 29, 2006·Journal of Clinical Pathology·C-Q ZhuM-S Tsao
Jul 5, 2011·Cancer Research·Fei YangIgnacio I Wistuba
Oct 19, 2006·Respiratory Research·Andriana I PapaioannouKonstantinos I Gourgoulianis
Jun 20, 2014·BMC Medical Genomics·Vijayalakshmi ShanmugamJohn D Carpten
Dec 4, 2009·Expert Opinion on Pharmacotherapy·Suwicha Limvorasak, Edwin M Posadas
Oct 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Paul Wheatley-Price, Frances A Shepherd
Mar 28, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Magdalena BieniaszJanusz Szemraj
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Thomas A d'AmatoJames D Luketich
Oct 18, 2015·Human Pathology·Matthew J CecchiniFrederick A Dick
Jun 30, 2006·International Journal of Clinical Practice·A YarenM Alakavuklar
Mar 17, 2010·Diagnostic Cytopathology·Viktor ShtilbansDavid E Burstein
May 4, 2005·Biochemical and Biophysical Research Communications·Kristina ViktorssonRolf Lewensohn
Jan 6, 2010·Critical Reviews in Oncology/hematology·David J Stewart
Mar 15, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eelco FokkemaHarry J M Groen
Dec 5, 2009·BMC Cancer·Sachin KumarBhudev C Das
Mar 21, 2015·PloS One·Yijun XueJinfeng Chen
Jul 14, 2010·Human & Experimental Toxicology·Christopher D Lindsay
May 30, 2019·Molecular and Cellular Biology·Aren E MarshallFrederick A Dick
Jun 17, 2014·Oncology Letters·Ahmed AbdallahRabab Gaafar
Apr 26, 2018·Nature Reviews. Cancer·Frederick A DickNicholas J Dyson
Feb 3, 2007·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Ricardo Luiz de Menezes Duarte, Marcos Eduardo Machado Paschoal
Jul 14, 2010·European Journal of Medical Research·J Chorostowska-WynimkoK Roszkowski-Sliz
Jun 10, 2010·Molecular Cancer Therapeutics·Jian-Zhong TangPeter E Lobie
May 23, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erick RiquelmeIgnacio I Wistuba
Nov 19, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Monique NilssonJohn V Heymach