Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers

Fertility and Sterility
Alexandra VodolazkaiaAmelie Fassbender

Abstract

To study single nucleotide polymorphisms (SNPs) involved in angiogenesis (VEGF, PLGF, VEGFR1, VEGFR2, HIF-1α) and plasma levels of the corresponding proteins (VEGF, PLGF, sVEGFR1, sVEGFR2) in women with and without endometriosis. Allele frequencies of vascular endothelial growth factor (VEGF) pathway SNPs and plasma levels of the corresponding proteins were investigated in patients with endometriosis and in controls. University hospital. Samples of DNA from 1,931 Caucasian patients were included (1,109 patients with endometriosis and 822 controls). An additional study group included 973 DNA samples from volunteers, self-reported to be healthy without laparoscopic evaluation. Women who underwent a laparoscopy for subfertility and/or pain and healthy volunteers without laparoscopic evaluation. Functional SNPs of the VEGF, VEGFR1, VEGFR2, HIF-1α genes and Hap Map tagging SNPs of the PLGF gene were genotyped by using iPLEX technology on a Sequenom MassArray and TaqMan SNP Genotyping Assay. The VEGF levels were determined in ethylenediaminetetraacetic acid plasma samples by using Bio-Plex Protein Array System. PLGF, sVEGFR1, and sVEGFR2 levels were measured in ethylenediaminetetraacetic acid plasma samples by using ELISA Quantikine ...Continue Reading

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Oct 21, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M R OrazovM A Sounov
Nov 12, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jéssica Vilarinho CardosoJamila Alessandra Perini
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