Vascular endothelial growth factor polymorphisms as effect modifiers of oral squamous cell carcinoma risk: A systematic review and meta-analysis

Molecular and Clinical Oncology
Carmen S MetzgerJuergen Brieger

Abstract

Smoking is one of the main risk factors for the development of oral squamous cell carcinoma (OSCC). Smoking may affect single-nucleotide polymorphism (SNP)-dependent vascular endothelial growth factor (VEGF)-induced angiogenic activity. Therefore, we systematically reviewed the published VEGF-SNP genotype data of OSCC patients and healthy individuals and performed a meta-analysis comparing the VEGF-SNP genotypes of smoking and non-smoking patients in association with OSCC incidence. Prospective and retrospective studies on the clinical comparison of OSCC patients with different VEGF-SNP genotypes were reviewed. The meta-analysis re-pooled studies of smoking and non-smoking OSCC patients with different VEGF-SNPs between 2006 and 2014. The identified articles were reviewed and those reporting pertinent information, assignment to smoking and non-smoking patient groups and sufficient data for estimation of an odds ratio (OR) with a 95% confidence interval (CI) were selected for the meta-analysis. Pooled ORs and CIs for the comparison of SNP distribution in the smoking and non-smoking subgroups were calculated and compared using the random-effects model. A total of 7 studies were included in the systematic review, which was followed...Continue Reading

References

Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams
Aug 30, 2002·Biochemical and Biophysical Research Communications·Yuichiro TanakaRajvir Dahiya
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophie-Elise MichaudAlain Rivard
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Peter KripplHellmut Samonigg
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qianren JinAsta Försti
Jun 7, 2005·Journal of Medical Genetics·W M HowellS Ye
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nobuhiko KataokaWei Zheng
Dec 5, 2006·International Journal of Oral and Maxillofacial Surgery·S Johnstone, R M Logan
Jun 15, 2007·Journal of Cancer Research and Clinical Oncology·C YapijakisE Patsouris
Feb 27, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Chieh-Yuan ChengShou-Yen Kao
Dec 10, 2008·Pharmacology & Therapeutics·Richard D EgletonPiyali Dasgupta
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bryan P SchneiderKathy D Miller
Apr 9, 2010·Clinical and Experimental Medicine·Claudiu MărgăritescuDomenico Ribatti
Jul 14, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Peer W KämmererJürgen Brieger
Dec 12, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P W KämmererJ Brieger
Sep 17, 2013·American Journal of Industrial Medicine·Ronald L BedfordR William Field
Feb 15, 2014·World Journal of Clinical Cases·Elena LionettiMario La Rosa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.