Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity

Nature Medicine
Lu ChenM Reza Dana

Abstract

There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.

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Jun 15, 2007·Archives of Ophthalmology·Lu ChenM Reza Dana
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