PMID: 9527324Apr 4, 1998Paper

Vascular endothelial growth factor (VEGF) in normal human corneal epithelium: detection and physiological importance

Acta Ophthalmologica Scandinavica
G B van Setten

Abstract

Corneal neovascularization is a major challenge following chemical burns and corneal inflammation. The factors triggering corneal neovascularization involve various growth factors. In the release and control of these factors the regenerating tissue plays a decisive role. Only recently has vascular endothelial growth factor been shown to be involved in the basic events of retinal neovascularization. From the cornea current knowledge allows only for the statement that corneal epithelium could be able to produce vascular endothelial growth factor. The present study was designed to show the presence of vascular endothelial growth factor-like substances in the corneal epithelium of the normal eye in vivo. Using specific antibodies to the N-terminus of human vascular endothelial growth factor indirect immuno-histochemistry was applied to sections of normal human corneal epithelium and to five sections of enucleated human eyes with a morphologically normal anterior segment. In all sections specific staining for vascular endothelial growth factor was found over the entire epithelium. Staining was most intense in the basal layer of epithelial cells. Only a weak staining was detectable in the cell layers closer to the surface. Here, howe...Continue Reading

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Citations

Jan 9, 2003·Current Eye Research·Arie L MarcovichYaron Bar-Dayan
Jul 29, 2010·Ocular Immunology and Inflammation·Sezin Akca BayarYonca A Akova
Dec 14, 2011·Cornea·Hamid HosseiniMahmood Nejabat
Nov 14, 2019·Journal of Clinical Medicine·Maria NotaraClaus Cursiefen
Jul 23, 1999·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M Kurpakus WheaterL D Hazlett
Apr 24, 2009·Cornea·Mohammad Reza KhaliliMorsal Mehryar
Apr 2, 2009·International Journal of Experimental Pathology·Fernando ChahudMaria C Roque-Barreira
Dec 14, 2017·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S AltanZ Oğurtan
Jun 13, 2002·Acta Ophthalmologica Scandinavica·Heather C Baldwin, John Marshall
Oct 1, 2019·Current Eye Research·Bhavani S Kowtharapu, Oliver Stachs
Nov 8, 2020·The American Journal of Pathology·Rodrigo G de SouzaCintia S de Paiva
Mar 20, 2020·Current Drug Targets·Giuseppe GiannaccareMassimo Busin
Jan 14, 2021·Toxicology Letters·Ariel GoreVered Horwitz
May 4, 2021·Experimental Eye Research·Praveen K BalneRajiv R Mohan
Dec 10, 2002·Experimental Eye Research·Chooi-May LaiP Elizabeth Rakoczy

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