Vascular endothelial growth factor (VEGF) expression in plasmacytoma

Leukemia & Lymphoma
S PaydaşIlhan Tuncer

Abstract

Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis. Although the role and importance of angiogenic factors such as VEGF have been established in various solid tumors, this has not been widely evaluated in hemopoietic neoplasias. In this trial, VEGF was studied in plasmacytoma and VEGF expression was compared with histopathologic grade. Forty-seven samples have taken from cases with plasmacytoma (Pm) (33 bones and 14 soft tissue plasmacytomas) were used as study material. Pm was the initial presentation in all cases, and bone marrow (BM) involvement was detected in 19 cases with systemic evaluation. Twenty-seven of the cases were male (age range was between 19 and 81 years). Histopathologically 27 cases had mature and 20 cases had immature morphology. Immunohistochemical analysis was used to detect VEGF expression and this was scored according to the percentage of the VEGF stained cells. VEGF expression was detected in 32 cases and in eight cases this expression was strong. In 11 cases expression was moderate and 13 cases showed mild expression. When we compared VEGF expression with pathologic grade, 17 of 20 immature samples showed VEGF expression while 15 of 27 mature samples showed VEGF expressi...Continue Reading

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Citations

Jul 12, 2003·Leukemia & Lymphoma·V Eleutherakis-PapaiakovouM A Dimopoulos
Jul 31, 2012·The American Journal of Medicine·Antoine NéelMohamed Hamidou
Nov 1, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C RibasJ O Bordin
Oct 24, 2002·Blood·Shaji KumarS Vincent Rajkumar
Dec 29, 2015·IUBMB Life·Sithul Hima, Sreeharshan Sreeja
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maurizio ZangariFrancis J Giles
Jan 23, 2004·Archives of Pathology & Laboratory Medicine·Xiao Yan YangKasturi Das

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