Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin

Circulation
T MuroharaJ M Isner

Abstract

Vascular endothelial growth factor (VEGF), an endothelial cell mitogen that promotes angiogenesis, was initially identified as a vascular permeability factor (VPF). Abundant evidence suggests that angiogenesis is preceded and/or accompanied by enhanced microvascular permeability. The mechanism by which VEGF/VPF increases vascular permeability (VP), however, has remained enigmatic. Accordingly, we used an in vivo assay of VP (Miles assay) to study the putative mediators of VEGF/VPF-induced permeability. VEGF/VPF and positive controls (platelet-activating factor [PAF], histamine, and bradykinin) all increased vascular permeability. Prior administration of the tyrosine kinase inhibitors genistein or herbimycin A prevented VEGF/VPF-induced permeability. Placenta growth factor, which binds to Flt-1/VEGF-R1 but not Flk-1/KDR/VEGF-R2 receptor tyrosine kinase, failed to increase permeability. Other growth factors such as basic fibroblast growth factor (FGF), acidic FGF, platelet-derived growth factor-BB, transforming growth factor-beta, scatter factor, and granulocyte macrophage-colony stimulating factor (8 to 128 ng) failed to increase permeability. VEGF/VPF-induced permeability was significantly attenuated by the nitric oxide (NO) sy...Continue Reading

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Sep 23, 1994·Cell·H H Schmidt, U Walter
Aug 1, 1993·The American Journal of Physiology·D D KuT A Brock
Jan 12, 1996·The Journal of Biological Chemistry·T CohenB Z Levi
Jun 1, 1996·The Journal of Surgical Research·M D HariawalaJ F Symes
Nov 15, 1996·The Journal of Biological Chemistry·R S WarrenD B Donner

❮ Previous
Next ❯

Citations

Dec 18, 2001·The Journal of Pathology·S A Abd-El-AleemG W Ireland
Feb 9, 2006·Cellular and Molecular Life Sciences : CMLS·S Cébe-SuarezK Ballmer-Hofer
Mar 3, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jincai LuoYao Lu
Aug 23, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Young Jung RohJung Il Moon
Feb 4, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·G B Arden, S Sivaprasad
Mar 9, 2005·Biochemical and Biophysical Research Communications·Chunying LiRichard C Venema
Aug 23, 2001·Thrombosis Research·F R Rickles, A Falanga
Apr 3, 2001·Trends in Pharmacological Sciences·M J Cross, L Claesson-Welsh
Dec 6, 2001·Diabetes Research and Clinical Practice·B P Yu, H Y Chung
Dec 1, 2001·Trends in Cardiovascular Medicine·T Murohara
Mar 18, 2003·International Immunopharmacology·Hiroshi MaedaYasunori Kitamoto
Mar 1, 2009·Animal : an International Journal of Animal Bioscience·S-P WuS-H Zhao
Aug 3, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Kai HuDawei Zhang
Jul 11, 2006·Nature Biotechnology·Roger G FahmyLevon M Khachigian
Aug 7, 2001·British Journal of Pharmacology·C Emanueli, P Madeddu
Nov 13, 2001·British Journal of Pharmacology·P N BernatchezM G Sirois
Jan 5, 2002·The Biochemical Journal·Roland GoversTon J Rabelink
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·J J Zwaginga, P Doevendans
Dec 10, 2002·Antioxidants & Redox Signaling·Toyoaki Murohara, Takayuki Asahara
May 19, 2007·Antioxidants & Redox Signaling·Donald G Buerk
Apr 20, 2010·Cardiovascular Research·David O Bates
Apr 12, 2012·Cardiovascular Research·Shyamal C BirJincai Luo
Oct 12, 2012·The Journal of Antimicrobial Chemotherapy·Ernest A AzzopardiDavid W Thomas
Aug 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paolo FabbriniJaap van den Born
Oct 17, 2003·Biology of Reproduction·Stina Häggström RudolfssonAnders Bergh
Nov 13, 1998·Current Opinion in Lipidology·M Laitinen, S Ylä-Herttuala
Jun 9, 2005·Critical Care Medicine·Jan Willem KuiperFrans B Plötz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.