Vascular endothelial injury in severe fever with thrombocytopenia syndrome caused by the novel bunyavirus

Virology
Xiao-Kun LiWei Liu

Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV) infection typically causes acute fever, thrombocytopenia and leucopenia, presenting with a high case fatality rate. The pathogenesis of SFTSV infection, however, is not well described. It was hypothesized that endothelial dysfunction might play part in the disease process. In current study, we retrospectively analyzed the clinical manifestations among a large group of confirmed SFTS cases and found evidence of plasma leakage and vascular endothelial injury. Then we established a SFTSV infection cell model and determined the infectivity and stimulation of SFTSV on vascular endothelial cells in vitro. The hyperpermeability of endothelial cells directly induced by SFTSV was confirmed by electrical resistance and dextran diffusion assay. The virus induced alterations of cell junctions and cytoskeleton was also revealed. It's suggested that vascular endothelial cell injury and barrier function damage were induced after SFTSV infection, which is a vital but neglected pathogenesis of SFTS.

References

Mar 23, 1995·Nature·L ShapiroW A Hendrickson
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·I N GavrilovskayaE R Mackow
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul W ThompsonAnne J Ridley
Jul 31, 2003·Thrombosis and Haemostasis·Ricardo Martin GomezMirta Schattner
Jun 17, 2004·Circulation·Jean Davignon, Peter Ganz
Dec 3, 2005·The Journal of Clinical Investigation·Bruce Furie, Barbara C Furie
Dec 14, 2007·The New England Journal of Medicine·Giovanni Davì, Carlo Patrono
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tsin W YeoNicholas M Anstey
Dec 8, 2009·Thrombosis and Haemostasis·Anon Srikiatkhachorn
Feb 26, 2010·Journal of Virology·Irina N GavrilovskayaErich R Mackow
Sep 8, 2010·The New England Journal of Medicine·Warren L Lee, Arthur S Slutsky
Aug 2, 2012·The Journal of Infectious Diseases·Zhong-Tao GaiDe-Xin Li
Apr 30, 2014·Anaesthesia·C S Alphonsus, R N Rodseth
May 20, 2014·The Lancet Infectious Diseases·Quan LiuXing-Quan Zhu
Jul 16, 2014·Antiviral Research·Anon Srikiatkhachorn, James F Kelley
Jan 31, 2015·Nature Communications·Laura HakanpaaPipsa Saharinen
Mar 11, 2015·The Journal of Cell Biology·Olga TornavacaMaria S Balda
Jun 27, 2015·Cellular and Molecular Life Sciences : CMLS·Junjun YangGuansong Wang
Jan 24, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stig NymoTom Eirik Mollnes
Dec 3, 2016·Virology Journal·Miao-Miao LiuXue-Jie Yu
Feb 6, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Sokha NhekJeffrey S Berger
May 31, 2017·Seminars in Immunopathology·Benjamin G ChoustermanGeorg F Weber
Jun 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jasmeet S ReyatMichael G Tomlinson
Jul 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Juan-Juan ZhuJing Zhou
Aug 15, 2017·PLoS Neglected Tropical Diseases·Xiao-Kun LiWei Liu
Oct 8, 2017·Methods in Molecular Biology·Melissa L TursiellaConnie S Schmaljohn

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Citations

Apr 9, 2019·Emerging Microbes & Infections·Shao-Fei ZhangWei Liu
May 29, 2019·PLoS Neglected Tropical Diseases·Shao-Fei ZhangWei Liu
Jan 8, 2021·International Journal of General Medicine·Fei WangZheng Ge
Jan 9, 2021·BMC Infectious Diseases·Hyungdon LeeYou Mi Lee

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