Vascular endothelium in immunology and infectious disease

Reviews of Infectious Diseases
M A Beilke

Abstract

During infection the vascular endothelial cell (EC) undergoes important immunologic alterations leading to increased leukocyte-EC adherence and initiation of a host inflammatory response. ECs express class 2 immune response genes and the interleukin 1 gene to a greater degree during infection and thus may be capable of amplifying the lymphocytic proliferative process. Lymphokines generated from stimulated lymphocytes, notably interferon-gamma, may in turn further enhance EC-leukocyte adherence and class 2 antigenic presentation by ECs. The ECs of different organ systems appear variable in terms of their immunologic capabilities. Infection of the endothelium has been demonstrated for an array of human pathogens, and even subclinical infection of ECs may ultimately assume importance in disease processes such as atherosclerosis. A potential role of the EC in the pathogenesis of newer infectious diseases, such as AIDS, is becoming evident and warrants further attention.

Citations

Mar 1, 1996·Archives of Dermatological Research·M B LappinM Norval
Aug 1, 1991·Journal of Neuroimmunology·M A BeilkeM Gravell
May 3, 2003·Methods : a Companion to Methods in Enzymology·E A Eugenin, Joan W Berman
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A M SteffanA Kirn
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A V MosesJ A Nelson
Dec 1, 1992·The Journal of Experimental Medicine·A A HurwitzJ W Berman
Aug 1, 1991·Australian Dental Journal·K W Knox, N Hunter
Jan 1, 1993·Annual Review of Medicine·A R Tunkel, W M Scheld
Aug 22, 2000·Equine Veterinary Journal·H BenbarekD Serteyn
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·O A Alexeyev
Jan 1, 1991·Annals of Medicine·V V Valtonen
Aug 1, 1992·Experimental and Molecular Pathology·M C SharmaV C Pandey
Jan 1, 1992·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·J W Berman, T M Calderon
Aug 12, 1999·Journal of the American Geriatrics Society·D HamermanD Silver
Mar 23, 2005·FEMS Immunology and Medical Microbiology·Eun-Kyoung ChoiIn-Chol Kang
Apr 1, 1994·Immunology and Cell Biology·S B WoodroffeJ E Layton
May 1, 1996·AIDS Research and Human Retroviruses·F DianzaniM R Capobianchi
Mar 1, 1991·Veterinary Pathology·J A EllisT R Haven
Jun 6, 2003·Angiology·Nirav J Mehta, Ijaz A Khan
Sep 1, 1992·AIDS Research and Human Retroviruses·M E LafonA Kirn
Feb 24, 2007·Medicinal Research Reviews·Y K AgrawalPathik Brahmkshatriya
Jan 10, 1998·Infection and Immunity·D A Drevets
Apr 1, 1993·Clinical Microbiology Reviews·A R Tunkel, W M Scheld
Nov 1, 1995·Infection and Immunity·D A DrevetsP A Campbell

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