Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial

BMJ : British Medical Journal
Mark J BollandI R Reid

Abstract

To determine the effect of calcium supplementation on myocardial infarction, stroke, and sudden death in healthy postmenopausal women. Randomised, placebo controlled trial. Academic medical centre in an urban setting in New Zealand. 1471 postmenopausal women (mean age 74): 732 were randomised to calcium supplementation and 739 to placebo. Adverse cardiovascular events over five years: death, sudden death, myocardial infarction, angina, other chest pain, stroke, transient ischaemic attack, and a composite end point of myocardial infarction, stroke, or sudden death. Myocardial infarction was more commonly reported in the calcium group than in the placebo group (45 events in 31 women v 19 events in 14 women, P=0.01). The composite end point of myocardial infarction, stroke, or sudden death was also more common in the calcium group (101 events in 69 women v 54 events in 42 women, P=0.008). After adjudication myocardial infarction remained more common in the calcium group (24 events in 21 women v 10 events in 10 women, relative risk 2.12, 95% confidence interval 1.01 to 4.47). For the composite end point 61 events were verified in 51 women in the calcium group and 36 events in 35 women in the placebo group (relative risk 1.47, 0.97 ...Continue Reading

References

Apr 1, 1986·Australian and New Zealand Journal of Medicine·I R ReidH K Ibbertson
Apr 23, 1994·BMJ : British Medical Journal·M C ChapuyP J Meunier
Sep 2, 1999·Stroke; a Journal of Cerebral Circulation·H IsoW C Willett
May 18, 2000·The New England Journal of Medicine·W G GoodmanI B Salusky
May 7, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M C ChapuyP J Meunier
Jun 26, 2002·Kidney International·Glenn M ChertowUNKNOWN Treat to Goal Working Group
Apr 14, 2005·The Journal of Clinical Endocrinology and Metabolism·Ian R ReidGregory D Gamble
Jun 3, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans-Gernot AsmusJürgen Bommer
Sep 2, 2006·The American Journal of Medicine·Ian R ReidGregory D Gamble
Feb 21, 2007·Circulation·Judith HsiaUNKNOWN Women's Health Initiative Investigators
Aug 21, 2012·The Medical Journal of Australia·David W JohnsonUNKNOWN Australasian Creatinine Consensus Working Group

❮ Previous
Next ❯

Citations

Feb 16, 2010·Aging Clinical and Experimental Research·Harald J J Verhaar
Feb 21, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I R ReidA Grey
Oct 15, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R L Prince, B E C Nordin
Dec 20, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ego Seeman
Jul 15, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E Seeman
Aug 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B EttingerL J Melton
Oct 6, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M J BollandI R Reid
Mar 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M KärkkäinenH Kröger
May 8, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P VestergaardL Mosekilde
Nov 26, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P IpA W C Kung
Mar 17, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I R ReidA Grey
Mar 17, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Burckhardt
Jun 3, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B E C NordinR L Prince
Sep 9, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M J BollandI R Reid
Feb 15, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-J BodyJ-Y Reginster
Apr 20, 2010·Zeitschrift für Rheumatologie·J Braun, J Pfeilschifter
Dec 1, 2009·European Journal of Nutrition·Giselle A P PignottiLígia A Martini
Jul 30, 2009·Wiener medizinische Wochenschrift. Supplement·Hans Peter DimaiUNKNOWN Austrian Society for Bone and Mineral Research (AuSBMR)
Jun 29, 2011·Reviews in Endocrine & Metabolic Disorders·Erik Fink Eriksen
Oct 14, 2011·Journal of General Internal Medicine·Judith M E WalshEleanor Bimla Schwarz
Dec 13, 2012·Current Atherosclerosis Reports·Pamela L Lutsey, Erin D Michos
Feb 26, 2009·Current Osteoporosis Reports·Jeri W Nieves
Aug 24, 2012·Current Osteoporosis Reports·Aloice O AluochLaura Carbone
Feb 23, 2011·The British Journal of Nutrition·David A CamfieldCon Stough
Aug 21, 2013·BoneKEy Reports·Loretta T RadfordIan R Reid
Jun 6, 2009·Nature Medicine·Brendan F Boyce
Jul 11, 2012·Nature Reviews. Cardiology·Ian R Reid, Mark J Bolland
Apr 5, 2012·Nature Reviews. Endocrinology·Bithika Thompson, Dwight A Towler
Aug 15, 2012·Nature Reviews. Rheumatology·Christos E LampropoulosDavid P D'Cruz
Feb 24, 2009·Journal of Nutrition for the Elderly·Gwendolen Buhr, Connie W Bales
Dec 10, 2009·The American Journal of Bioethics : AJOB·Beatrice Alexandra Golomb
Aug 11, 2012·Age and Ageing·Frederik H VerbruggeSteven Boonen
Feb 12, 2009·American Journal of Epidemiology·Kyong ParkDavid R Jacobs
May 11, 2012·American Journal of Epidemiology·Elizabeth R Bertone-JohnsonJoann E Manson
Dec 19, 2008·International Journal of Epidemiology·Wasim Maziak
Sep 5, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc G Vervloet, Jos W R Twisk
Jun 27, 2008·Menopause : the Journal of the North American Menopause Society·Wulf H UtianUNKNOWN North American Menopause Society
Feb 4, 2009·Menopause : the Journal of the North American Menopause Society·Stefan VegterLolkje T W de Jong-van den Berg
Jun 17, 2010·Menopause : the Journal of the North American Menopause Society·JoAnn E MansonUNKNOWN Women's Health Initiative and Women's Health Initiative-Coronary Artery Calcium Study Investigators
Jun 17, 2010·Menopause : the Journal of the North American Menopause Society·Michael F Holick
Apr 27, 2011·Current Opinion in Nephrology and Hypertension·Geoffrey A Block
May 7, 2011·Current Opinion in Nephrology and Hypertension·Grahame J Elder
Jul 20, 2010·Seminars in Dialysis·Gérard M London
Nov 13, 2010·International Journal of Clinical Practice·M J BollandI R Reid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.