Vascular function assessed with cardiovascular magnetic resonance predicts survival in patients with advanced chronic kidney disease.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
Patrick B MarkAlan G Jardine

Abstract

Increased arterial stiffness is associated with mortality in patients with chronic kidney disease. Cardiovascular magnetic resonance (CMR) permits assessment of the central arteries to measure aortic function. We studied the relationship between central haemodynamics and outcome using CMR in 144 chronic kidney disease patients with estimated glomerular filtration rate <15 ml/min (110 on dialysis). Aortic distensibilty and volumetric arterial strain were calculated from cross sectional aortic volume and pulse pressure measured during the scan. Median follow up after the scan was 24 months. There were no significant differences in aortic distensibilty or aortic volumetric arterial strain between pre-dialysis and dialysis patients. Aortic distensibilty and volumetric arterial strain negatively correlated with age. Aortic distensibilty and volumetric arterial strain were lower in diabetics, patients with ischaemic heart disease and peripheral vascular disease. During follow up there were 20 deaths. Patients who died had lower aortic distensibilty than survivors. In a survival analysis, diabetes, systolic blood pressure and aortic distensibilty were independent predictors of mortality. There were 12 non-fatal cardiovascular events d...Continue Reading

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Citations

Nov 20, 2009·International Urology and Nephrology·Mehmet KanbayAdrian Covic
Oct 2, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Petr MachekPeter Wabel
Apr 7, 2009·European Journal of Radiology·Susanne C Ladd
Aug 26, 2015·European Radiology·Robert C BertheauChristopher L Schlett
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Shahram Shams HakimiMona Salahi
Nov 28, 2012·Orvosi hetilap·Attila Nemes, Tamás Forster
Aug 25, 2011·Nature Reviews. Nephrology·Cristina KarohlPaolo Raggi
Nov 12, 2009·Circulation. Heart Failure·Scott J DenardoWilmer W Nichols
Feb 20, 2019·Journal of Nephrology·Richard B ThompsonUNKNOWN Alberta Kidney Disease Network
Mar 25, 2019·Seminars in Dialysis·Matthew P M Graham-BrownJames O Burton
Dec 2, 2020·The International Journal of Cardiovascular Imaging·Sherna F AdenwallaMatthew P M Graham-Brown
Mar 21, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jennifer S LeesPatrick B Mark

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