PMID: 9183544Apr 1, 1997Paper

Vascular gene transfer

Current Opinion in Lipidology
S Ylä-Herttuala

Abstract

Vascular gene transfer may be useful for the treatment of several cardiovascular diseases. It can also be used as an experimental tool to test the effects of various genes in a local vascular compartment. Promising therapeutic effects have been obtained in animal models of restenosis with the transfer of vascular endothelial growth factor, nitric oxide synthase, thymidine kinase, retinoblastoma, growth arrest homeobox gene, cyclin/cyclin-dependent kinase inhibitor (p21), and hirudin genes, and antisense oligonucleotides against transcription factors or cell cycle regulatory proteins. Vascular endothelial growth factor and fibroblast growth factor gene transfers have improved blood flow and capillary development in models of ischaemic limb and myocardium. First experiences of vascular endothelial growth factor gene transfer to human peripheral arteries have also been reported. However, further developments in gene delivery techniques and gene transfer vectors will be required before a full therapeutic potential of gene therapy in cardiovascular diseases can be evaluated.

Citations

Dec 21, 2000·Current Atherosclerosis Reports·T Pakkanen, S Ylä-Herttuala
Jul 27, 2001·Molecular Aspects of Medicine·G M Rubanyi
Feb 16, 2000·Lancet·S Ylä-Herttuala, J F Martin
May 19, 2000·Experimental Gerontology·M P TurunenS Ylä-Herttuala
Jul 18, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sneha SundaramUday B Kompella
Nov 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sneha SundaramUday B Kompella
Feb 13, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·J M LassoR Pérez Cano
Oct 20, 2005·European Journal of Radiology·Hannu I Manninen, Xiaoming Yang
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·I ZacharyJ Martin
Dec 2, 1999·Nature Medicine·N Ferrara, K Alitalo
Nov 13, 1998·Current Opinion in Lipidology·M Laitinen, S Ylä-Herttuala
May 25, 1999·Perfusion·A Basile-BorgiaH Mahloogi
May 18, 1999·The Veterinary Record·D J Argyle

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