PMID: 11319735Apr 25, 2001Paper

Vascular graft healing. II. FTIR analysis of polyester graft samples from implanted bi-grafts

Journal of Biomedical Materials Research
D J LymanE S Wijelath

Abstract

FTIR-ATR analysis has shown that the 4-step process for preclotting polyester vascular grafts results in a uniform and reproducible fibrin coating of the polyester fibers. Western blot analyses have shown that FN and VEGF are also present in this fibrin coating. FTIR-ATR analyses of explanted grafts indicate that, while the in vivo healing of these preclotted polyester grafts proceed through the inflammation, proliferation, and remodeling phases of normal wound healing, these phases are modified. Because the fibrin coating provides a nonporous barrier between peri-graft tissue and the flowing blood, these molecular changes are controlled by the interactions of blood-borne constituents with the lumenal surface of the preclotted graft. Also, a well prepared preclotted polyester graft shows a minimal inflammatory response. After implantation, the fibrin preclot is more than 90% gone by the fifth day. However, the proliferation phase, involving synthesis of new protein and polysaccharide materials to replace the fibrin, appears to have begun by the third day. Detection of collagen I in the 5-day explants suggests that the overlapping remodeling phase of healing has begun. Protein and saccharide materials continue to be synthesized ...Continue Reading

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May 20, 1999·Journal of Biomedical Materials Research·D J Lyman, J Murray-Wijelath

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Citations

Aug 11, 2007·Biomaterials·Peter ZillaPaul Human
Feb 4, 2014·Journal of Biomedical Materials Research. Part a·Nuno AlexandreAna Lúcia Luís
May 11, 2006·Journal of Biomaterials Applications·Ruben Y KannanAlexander M Seifalian
Jul 21, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jacqueline Murray-WijelathErrol S Wijelath
Nov 10, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Donald J LymanErrol Wijelath

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