Vascular hyporesponsiveness to endothelin 1 in rats with cirrhosis

Gastroenterology
M HartlebD Lebrec

Abstract

Because the vasodilator nitric oxide is overproduced in cirrhosis, this substance may decrease pressor responses to the vasoconstrictor endothelin 1. This study aimed to examine the effects of a NO synthesis inhibitor (NG-nitro-L-arginine methyl ester; L-NAME) on vascular responsiveness to endothelin 1 in normal and cirrhotic rats. Pressor dose-response curves to endothelin 1 (0.5, 1, 3, 6, and 10 micrograms/kg intravenously) were obtained in animals with or without pretreatment with L-NAME. Pressor responses to endothelin 1 alone were significantly lower in cirrhotic than in normal rats. In cirrhotic animals, pressor responses to 3, 6, and 10 micrograms/kg of endothelin 1 were significantly higher in the presence than in the absence of L-NAME. The responses to the other doses of endothelin 1 were not affected by L-NAME. In normal rats, pressor responses to all doses of endothelin 1 were significantly higher in the presence than in the absence of L-NAME. In animals pretreated with L-NAME, pressor responses to 6 and 10 micrograms/kg of endothelin 1 did not differ between cirrhotic and normal rats, whereas responses to other doses remained lower in cirrhotic than in normal rats. In rats with cirrhosis, NO seems to contribute to v...Continue Reading

Citations

Nov 14, 1997·The American Journal of Physiology·K A TaziD Lebrec
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M C HouJ V Sitzmann
Aug 26, 1998·The New England Journal of Medicine·P Y MartinR W Schrier
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SogniD Lebrec
Mar 29, 2000·Journal of Gastroenterology and Hepatology·S MigohK Sugimachi
Apr 6, 2001·International Journal of Clinical & Laboratory Research·C M BrunoL Caruso
Jan 22, 2003·Journal of Gastroenterology and Hepatology·D Kapoor, S K Sarin
Jan 15, 2008·Pflügers Archiv : European journal of physiology·Toshishige ShibamotoShozo Koyama
Jul 25, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nicholas G TheodorakisNicholas J Skill
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N M AtuchaJ García-Estañ
May 7, 2015·World Journal of Gastroenterology : WJG·Nicholas TheodorakisNicholas Skill
Oct 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·S Møller, J H Henriksen
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A HeinemannR E Stauber
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A CahillJ V Sitzman
Nov 30, 2000·American Journal of Physiology. Renal Physiology·L XuR W Schrier
Jun 26, 2001·Liver·R Farzaneh-Far, K Moore
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reiner Wiest, Roberto J Groszmann
Dec 6, 2007·Journal of Clinical Gastroenterology·Reiner Wiest
Aug 20, 2020·Cephalalgia : an International Journal of Headache·Bianca N MasonAndrew F Russo
May 4, 2001·International Journal for Parasitology·S B PetkovaH B Tanowitz
May 20, 1998·Nutrition·B Alexander
Mar 1, 1995·Journal of Hepatology·R Moreau, D Lebrec

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