Vascular invasion in squamous cell carcinomas of human oral mucosa

Oral Oncology
K NiimiT Saku

Abstract

The process of vascular invasion of human oral squamous cell carcinomas was histologically and immunohistochemically studied in surgical and autopsy specimens. Hematoxylin-eosin, Masson's trichrome, and immunohistochemical stainings for Ulex europaeus I lectin binding, CD31, and type IV collagen were done to differentiate lymphatic and blood vessels and to demonstrate basement membranes in vascular walls and around carcinoma cell nests was observed. With growth of tumor, there was mechanical disruption of vascular walls and endothelial cells by carcinoma cell nests. After disrupting vascular walls, they invaded into the lumen as clusters, not as single cells. At the blood vessel invasion sites, inflammatory reactions were seen around carcinoma cell nests inside as well as outside lumina with microthrombotic reactions due to endothelial injury. At the lymphatic invasion sites, carcinoma cell nests maintained their volume inside the lumen and the cells adhered tightly to each other, and inflammatory reaction was scarcely seen. These findings showed that mechanical pressure has an important role in the vascular invasion of human oral squamous cell carcinoma.

References

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·P ConstantinidesM Harkey
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·P ConstantinidesS Jue
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
Oct 1, 1983·The American Journal of Surgical Pathology·S H BarskyL A Liotta
Apr 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·K OhtakeT Nakajima
Jul 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S ShingakiT Nakajima

❮ Previous
Next ❯

Citations

Aug 3, 2004·Cancer Biotherapy & Radiopharmaceuticals·Gary Ross
Mar 9, 2010·Diagnostic Pathology·Xiaoqi LinJan F Silverman
Jan 30, 2007·Pathology, Research and Practice·Sukalyan KunduTakashi Saku
Jun 16, 2009·Microscopy Research and Technique·Yung-Nien SunSen-Tien Tsai
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Grimm
Mar 23, 2006·Journal of Cellular Biochemistry·William C ConwayMarc D Basson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.