Vascular Mechanisms and Molecular Targets in Hypertensive Pregnancy and Preeclampsia

American Journal of Physiology. Heart and Circulatory Physiology
Hongmei Qu, Raouf A Khalil


Preeclampsia is a major complication of pregnancy manifested as hypertension and often intrauterine growth restriction, but the underlying pathophysiological mechanisms are unclear. Predisposing genetic and environmental factors cause placental maladaptations leading to defective placentation, apoptosis of invasive cytotrophoblasts, inadequate expansive remodeling of the spiral arteries, reduced uteroplacental perfusion pressure and placental ischemia. Placental ischemia promotes the release of bioactive factors into the maternal circulation, causing an imbalance between anti-angiogenic soluble fms-like tyrosine kinase-1 and soluble endoglin, and pro-angiogenic vascular endothelial growth factor, placental growth factor and transforming growth factor-β. Placental ischemia also stimulates the release of proinflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin type 1 receptor agonistic autoantibodies. These circulating factors target the vascular endothelium, causing generalized endotheliosis in systemic, renal, cerebral and hepatic vessels, leading to decreases in endothelium-derived vasodilators such as nitric oxide, prostacyclin and hyperpolarization factor, and increases in vasoconstrictor...Continue Reading


Mar 1, 1991·The American Journal of Physiology·R R MagnessB R Carr
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R N TaylorJ M Roberts
Nov 1, 1973·The Journal of Clinical Investigation·N F GantP C MacDonald
Dec 1, 1996·American Journal of Obstetrics and Gynecology·G A Knock, L Poston
Jun 13, 1998·Biochimica Et Biophysica Acta·C S WingroveJ C Stevenson
Jan 12, 1999·The Journal of Clinical Investigation·A YachieS Koizumi
Apr 9, 1999·The Journal of Clinical Investigation·G WallukatF C Luft
Jul 17, 1999·The American Journal of Physiology·K P ConradM D Mosher
Sep 7, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·H SekiK Satoh
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C A KanashiroR A Khalil
Mar 4, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A H ShaamashH M EL-dien
Mar 10, 2000·Seminars in Perinatology·K L ThornburgM J Morton
Jun 28, 2000·Cardiovascular Research·M J VanWijkE VanBavel
Dec 21, 2000·American Journal of Physiology. Cell Physiology·C A Kanashiro, R A Khalil
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J G MurphyR A Khalil
Apr 13, 2001·JAMA : the Journal of the American Medical Association·J C ChambersJ S Kooner
Sep 25, 2001·American Journal of Obstetrics and Gynecology·E E FulepR E Garfield
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F ScaleraE Beinder
Jan 26, 2002·American Journal of Obstetrics and Gynecology·Marja J VanWijkEd VanBavel
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jason G MurphyRaouf A Khalil
Nov 16, 2002·The Journal of Physiology·Yoshikatsu SuzukiTakeo Itoh
Feb 11, 2004·Hypertension·Barbara T AlexanderJoey P Granger
Feb 14, 2004·Gynecologic and Obstetric Investigation·Takayuki IwakiNaohiro Kanayama
May 1, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Thomas KraussHellmut G Augustin
Aug 31, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Q QiuA Gruslin
Oct 13, 2004·The Journal of Experimental Medicine·Susan E HibyAshley Moffett
Oct 14, 2004·Clinical and Experimental Pharmacology & Physiology·Harold A ColemanHelena C Parkington
Nov 24, 2004·Journal of Vascular Surgery·David K W ChewRaouf A Khalil
Mar 1, 2005·Lancet·Baha SibaiMichael Kupferminc

❮ Previous
Next ❯


Apr 3, 2021·American Journal of Physiology. Heart and Circulatory Physiology·María M PereiraDaniel Bia
May 8, 2021·Clinical Science·Anna E StanhewiczGary L Pierce
May 6, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luca ValsecchiGianpaolo Zerbini

❮ Previous
Next ❯

Related Concepts

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2021 Meta ULC. All rights reserved