Vascular mineralocorticoid receptor and blood pressure regulation

Current Opinion in Pharmacology
Antoine TarjusFrédéric Jaisser

Abstract

The mineralocorticoid receptor (MR) is a major regulator of blood pressure by modulating sodium balance and blood volume in the distal nephron. The discovery of MR expression in both endothelial and vascular smooth muscle cells a decade ago raised questions about its role in the vascular wall and its involvement in blood pressure regulation. In vitro and in vivo pharmacological studies have shown that vascular MR is involved in several vascular properties such as extracellular matrix remodeling, inflammation and vascular reactivity. In this review, we focus on recent advances obtained using transgenic model with cell-specific modulation of the expression MR in endothelium or smooth muscle and their impact on blood pressure.

References

Dec 12, 1966·JAMA : the Journal of the American Medical Association·R L WolfA Weigl
Oct 5, 2002·Hypertension·Agostino VirdisErnesto L Schiffrin
Jan 18, 2005·Lancet·Patricia M KearneyJiang He
May 10, 2007·The Journal of Clinical Endocrinology and Metabolism·Hylton V JoffeGail K Adler
Sep 25, 2007·Pflügers Archiv : European journal of physiology·Kristina Kusche-VihrogHans Oberleithner
Feb 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Youngtae JeongCharles J Lowenstein
Mar 20, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aurelie Nguyen Dinh CatFrederic Jaisser
Jun 5, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Antonio VukusichElisa T Marusic
Aug 11, 2010·The Journal of Clinical Investigation·Michael G UsherRichard M Mortensen
Aug 5, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Arihiro KiyosueYasunobu Hirata
Dec 14, 2011·The Journal of Endocrinology·Peter J FullerMorag J Young
Apr 21, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katy Sánchez-PozosNorma A Bobadilla
Jun 12, 2012·The Journal of Clinical Investigation·Min ZhaoFrancine Behar-Cohen
Sep 27, 2012·Journal of Hypertension·GianLuca ColussiLeonardo A Sechi
Jan 10, 2013·The Journal of Clinical Investigation·Jakob VoelklFlorian Lang
Mar 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ioana R PrestonIris Z Jaffe
Mar 6, 2013·Hypertension·Pia JeggleKristina Kusche-Vihrog
Apr 19, 2013·European Heart Journal·Nicola SchäferChristian M Matter
May 25, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Stephan SickingerFelix Aigner
Jan 15, 2014·Nature Reviews. Nephrology·David G WarnockFrederic Jaisser
Apr 23, 2014·Hypertension·Gary F Mitchell
Jul 23, 2014·Endocrinology·Katelee Barrett MuellerIris Z Jaffe
Sep 23, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Heba AdelMohamed M A Khalifa

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Citations

Jun 7, 2019·The Journal of Clinical Hypertension·Michael A Hill, James R Sowers
Oct 17, 2019·Foods·Mikkel R DeutchMarcus Krüger
Apr 5, 2017·Frontiers in Pediatrics·John S Torday, Heber C Nielsen
Aug 16, 2018·Current Hypertension Reports·Manav NayyarCamila Manrique Acevedo
Nov 12, 2017·Scientific Reports·Stefanie RuhsClaudia Grossmann
Jul 26, 2018·Neuroscience and Biobehavioral Reviews·Julia J MüllerMatthias Schwab

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