Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

Proceedings of the National Academy of Sciences of the United States of America
H UyttendaeleJan Kitajewski

Abstract

Notch proteins function as receptors for membrane-bound ligands (Jagged and Delta-like) to regulate cell-fate determination. We have investigated the role of Notch signaling in embryonic endothelium of the mouse by expressing an activated form of the Notch4 protein in vasculature under the regulation of the Flk1 (VEGFR) locus. Expression of activated Notch4 results in a growth and developmental delay and embryonic lethality at about 10 days postcoitum. The extent of the developing vasculature in mutant embryos was restricted, fewer small vessels were seen, and vascular networks were disorganized. The brain periphery of mutant embryos contained large dilated vessels with evidence of compromised vessel-wall integrity and large areas of necrosis; yolk-sac vasculature was abnormal. Expression of an activated form of Notch4 in embryonic vasculature leads to abnormal vessel structure and patterning, implicating the Notch pathway in phases of vascular development associated with vessel patterning and remodeling.

References

Nov 1, 1991·Trends in Genetics : TIG·S Artavanis-Tsakonas, P Simpson
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P M WongC J Eaves
Jan 1, 1986·Tissue & Cell·D E Sims
Sep 1, 1983·Cell·I S GreenwaldH R Horvitz
Feb 1, 1993·Anatomy and Embryology·L Pardanaud, F Dieterlen-Lièvre
Dec 31, 1993·Cell·M E Fortini, S Artavanis-Tsakonas
Jan 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V L BautchT A Futch
Apr 17, 1997·Nature·W Risau
Apr 17, 1997·Nature·M Hrabĕ de AngelisA Gossler
Mar 1, 1997·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y ShirayoshiN Nakatsuji
Jun 24, 1998·Genes & Development·I Greenwald
Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L Robb, A G Elefanty
Apr 10, 1999·Human Molecular Genetics·Y XueT Gridley
Jun 8, 1999·Annual Review of Immunology·E Robey
Mar 31, 2000·Nature Medicine·P Carmeliet
Aug 31, 2000·Microvascular Research·H UyttendaeleJ Kitajewski

❮ Previous
Next ❯

Citations

Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Farrah Kheradmand, Zena Werb
Jul 4, 2002·International Journal of Hematology·K OhishiI D Bernstein
Jun 20, 2008·Breast Cancer Research and Treatment·Anita L BaneIrene L Andrulis
Sep 2, 2006·Journal of Mammary Gland Biology and Neoplasia·Wen Shi, Adrian L Harris
May 18, 2004·Biology of the Cell·Alfonso BaldiAntonio De Luca
Nov 30, 2002·Trends in Pharmacological Sciences·Andreas Bikfalvi, Roy Bicknell
Aug 19, 2003·Trends in Cardiovascular Medicine·Andreas Fischer, Manfred Gessler
Sep 5, 2002·Nature Reviews. Genetics·Nathan D Lawson, Brant M Weinstein
Jun 12, 2013·Nature Reviews. Nephrology·Binita M KamathNorman D Rosenblum
Sep 2, 2008·Oncogene·J DufraineJ Kitajewski
Jan 19, 2002·Differentiation; Research in Biological Diversity·C MailhosD Ish-Horowicz
Feb 18, 2003·Journal of Anatomy·Ralf H Adams
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick A MurphyRong A Wang
Oct 9, 2009·Brain : a Journal of Neurology·Qichuan ZhuGeKunlin Jin
Oct 2, 2009·Carcinogenesis·Liang Qiao, Benjamin C Y Wong
Aug 18, 2004·Current Opinion in Hematology·Jackelyn A Alva, M Luisa Iruela-Arispe
Mar 13, 2012·Current Opinion in Hematology·Courtney K Domigan, M Luisa Iruela-Arispe
Oct 7, 2004·Genes & Development·António DuarteJanet Rossant
Jan 21, 2012·Science Translational Medicine·Jan Kitajewski
Jan 16, 2007·Molecular and Cellular Biology·Jing Wu, Emery H Bresnick
Mar 23, 2002·Molecular and Cellular Biology·Kevin G LeongAly Karsan
Aug 5, 2003·Molecular and Cellular Biology·Keisuke HoriuchiCarl P Blobel
Feb 3, 2005·Molecular and Cellular Biology·Jing WuEmery H Bresnick
Aug 19, 2008·Biochemistry. Biokhimii︠a︡·A F Karamysheva
Mar 11, 2005·Canadian Journal of Physiology and Pharmacology·Aly Karsan
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Janet Rossant, Lorraine Howard
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Roy Bicknell, Adrian L Harris
Nov 26, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Doug MiniatiRong A Wang
Dec 22, 2011·International Journal of Vascular Medicine·Masahiro Murakami
Apr 6, 2005·Circulation·Florian P LimbourgJames K Liao
Oct 20, 2007·The Journal of Clinical Investigation·Carrie J ShawberJan Kitajewski
Aug 7, 2012·Genes & Cancer·Natalie M KoflerJan Kitajewski
Mar 1, 2011·BMC Developmental Biology·Jessica N CopelandJay L Vivian
Dec 18, 2009·Journal of Angiogenesis Research·Tsutomu Kume

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.