Vascular permeability and hemodynamic effects of ulinastatin on organs affected by shock during early burn injury

The American Journal of Emergency Medicine
Shiyan LiHaizhou Yu

Abstract

This study aimed to investigate the preventive and therapeutic effects of ulinastatin on the recovery of vascular permeability and hemodynamics in shock-affected organs during early burn injury. Twelve beagle dogs with 35% TBSA full-thickness burn were randomized to control group (CG, n = 6) and ulinastatin group (UG, n = 6).Hemodynamic parameters were determined by PICCO before burn and at 0.5 h, 1 h, 2 h, 4 h, 6 h, 8 h post-burn. Plasma volume (PV) were deduced through indocyanine green (ICG) method. Blood samples were drawn to determine hematocrit (HCT) at each time. Intestinal mucosal blood flow (IMBF) was determined by laser Doppler flowmetry. Evans blue (EB) method was taken to measure the vasopermeability of heart, liver, spleen, kidney and small intestine. Pathological tests were also performed. Compared with CG,UG had better hemodynamic parameters (improved mean arterial pressure and cardiac output) (P < 0.05). HCT rose in both groups, while in UG the rising extent was less than that in CG (P < 0.05). PV and IMBF in both groups declined, but in UG the extent were less (P < 0.05). Both EB content of liver, spleen, kidney and small intestine in UG were much lower than that in CG at 8 h post-burn (P < 0.05). Pathological ...Continue Reading

Citations

Mar 29, 2020·The Journal of International Medical Research·Xueli HuXianming Zhang
Jun 29, 2021·Frontiers in Medicine·Christoph SchrieflMichael Schwameis

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