Vascular permeability factor, an endothelial cell mitogen related to PDGF.

Science
P J KeckD T Connolly

Abstract

Vascular permeability factor (VPF) is a 40-kilodalton disulfide-linked dimeric glycoprotein that is active in increasing blood vessel permeability, endothelial cell growth, and angiogenesis. These properties suggest that the expression of VPF by tumor cells could contribute to the increased neovascularization and vessel permeability that are associated with tumor vasculature. The cDNA sequence of VPF from human U937 cells was shown to code for a 189-amino acid polypeptide that is similar in structure to the B chain of platelet-derived growth factor (PDGF-B) and other PDGF-B-related proteins. The overall identity with PDGF-B is 18%. However, all eight of the cysteines in PDGF-B were found to be conserved in human VPF, an indication that the folding of the two proteins is probably similar. Clusters of basic amino acids in the COOH-terminal halves of human VPF and PDGF-B are also prevalent. Thus, VPF appears to be related to the PDGF/v-sis family of proteins.

References

May 1, 1986·Microvascular Research·L E Gerlowski, R K Jain
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Jan 1, 1985·Advances in Cancer Research·J Folkman
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Jan 10, 1986·Nucleic Acids Research·H S BilofskyC S Tung
Jan 10, 1986·Nucleic Acids Research·G H Hamm, G N Cameron

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Citations

Sep 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G H FongM L Breitman
Sep 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·O CleaverP A Krieg
Nov 20, 1997·Journal of Cellular Physiology·I FlammeW Risau
Sep 21, 2000·Journal of Cellular Biochemistry·F VillarsJ Amédée
Dec 13, 2000·Diabetes/metabolism Research and Reviews·S ChakrabartiS Chen
Nov 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G BreierW Risau
Jul 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·James M GreenbergAnn L Akeson
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Oct 18, 2002·International Journal of Cancer. Journal International Du Cancer·Cornelia HalinDario Neri
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D S WangK Sato
Aug 14, 2001·Journal of Cellular Biochemistry·T YamamotoT Uematsu
Nov 1, 1991·Journal of Cellular Biochemistry·C H HeldinK Miyazono
Nov 1, 1991·Journal of Cellular Biochemistry·N FerraraD W Leung
Nov 1, 1991·Journal of Cellular Biochemistry·D T Connolly
Aug 1, 1990·Journal of Cellular Physiology·J LaterraG W Goldstein
Apr 15, 1994·Microscopy Research and Technique·C L Farrell, W Risau
Mar 15, 1997·Developmental Biology·A Tufro-McReddieR A Gomez
Jun 1, 1996·Cancer Metastasis Reviews·B I Terman, M Dougher-Vermazen
Jun 1, 1996·Cancer Metastasis Reviews·K P Claffey, G S Robinson
Jun 1, 1996·Cancer Metastasis Reviews·K H Plate
Jan 1, 1995·Breast Cancer Research and Treatment·N Ferrara
Jan 1, 1995·Breast Cancer Research and Treatment·W KolchD Marmé
Jul 1, 1992·European Journal of Pediatrics·L Schweigerer, T Fotsis
Jun 1, 1999·Endocrine Pathology·S VidalB W Scheithauer

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