PMID: 7545558Jan 1, 1995Paper

Vascular proliferation and angiogenic factors in psoriasis

Clinical and Experimental Dermatology
J D Creamer, J N Barker

Abstract

Psoriasis is a common, chronic skin disorder characterized by hyperproliferation of the epidermis, inflammatory cell accumulation and increased tortuosity and dilatation of dermal papillary blood vessels. Research into the pathogenesis of psoriasis has concentrated mainly on the interplay between inflammatory cells and epidermal proliferation. Central to the proposed pathogenetic pathway are cytokines produced by activated keratinocytes, which are thought to induce both keratinocyte proliferation and lymphocyte migration. Cytokines also mediate upregulation of adhesion molecules on vascular endothelium which in turn permits lymphocyte recruitment. The close spatial relationship between altered microvasculature and epidermis is clearly important in psoriasis. Consequently, understanding the mechanisms underlying vascular changes is fundamental to an elucidation of pathogenetic mechanisms in psoriasis.

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Citations

Mar 24, 2004·Micron : the International Research and Review Journal for Microscopy·Terence Ryan
Apr 28, 2012·BMC Research Notes·Siaw-Cheok LiewAdawiyah Jamil
Feb 14, 2004·The Journal of Investigative Dermatology·Helen S YoungChristopher E M Griffiths
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Mar 17, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Mahsa Sadat HosseiniBehrouz Gharesi-Fard

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