PMID: 2106294Feb 1, 1990Paper

Vascular properties of canine lungs perfused with Eurocollins solution and prostacyclin

The Annals of Thoracic Surgery
H UnruhL Oppenheimer

Abstract

Although Eurocollins solution (ECS) is commonly used for lung preservation, its vascular effects and their time course and response to pharmacological interventions are not well understood. The effect of 4 degrees C ECS on the pulmonary circulation was assessed in excised canine left lower lobes. The roles of static oxygen inflation and prostacyclin infusion during ECS perfusion were also examined. The lobes were divided into five groups: time control (A), ECS with oxygen (B), ECS without oxygen (C), ECS with glycine buffer (D), and ECS with prostacyclin (E); group D was the control for E. Eurocollins solution had no effect on gas exchange but had a marked effect on the pulmonary circulation. Vascular conductance decreased from 22.6 to 18.9 mL/min/cm H2O and from 21.3 to 14.1 mL/min/cm H2O with average vascular closure increasing by 1.2 and 2.1 cm H2O in groups B and C, respectively. The decreased vascular conductance and increased vascular closure was associated with a reduction in vascular compliance from 1.63 to 1.25 mL/cm H2O. When prostacyclin was added to ECS, the reduction in vascular closure was much less and was associated with a decrease in vascular closure and no loss of vascular compliance. Eurocollins solution incr...Continue Reading

References

Apr 1, 1983·Transplantation·F J VeithC M Montefusco
Apr 1, 1982·Circulation Research·R GrahamH S Goldberg

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Citations

Jun 26, 2003·The Annals of Thoracic Surgery·Rosemary F KellyE Kenneth Weir
Apr 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A ParryJ Wallwork
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
May 1, 1991·The Annals of Thoracic Surgery·R J NovickF N McKenzie
Sep 1, 1994·The Annals of Thoracic Surgery·P O Kimblad, S Steen
Sep 1, 1991·The Annals of Thoracic Surgery·P O KimbladS Steen
Dec 29, 2000·The Journal of Laboratory and Clinical Medicine·R F Kelly
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Dilip S NathRosemary F Kelly
Jul 1, 1997·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·P Santillan-DohertyI Cedillo-Ley
Sep 26, 1997·The Journal of Thoracic and Cardiovascular Surgery·A WatanabeH Takahashi
Jan 1, 1991·Annales Françaises D'anesthèsie Et De Rèanimation·D LafontP Herve

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