PMID: 9540129Apr 16, 1998Paper

Vascular remodeling and endothelial function in hypertensive patients: effects of antihypertensive therapy

Scandinavian Cardiovascular Journal. Supplement
E L Schiffrin

Abstract

To review studies of effects of antihypertensive agents on alterations in structure and function of small (resistance-size) arteries in hypertensive patients and in experimental hypertensive models, since these vessels may contribute to blood pressure elevation or to the complications of hypertension. The structure and endothelium-dependent relaxation of small arteries obtained in hypertensive humans from gluteal subcutaneous biopsies, and from different vascular beds in hypertensive rats, without and after antihypertensive treatment, and studied on a wire-myograph or as pressurized arteries, are described as reported in different studies. Treatment of spontaneously hypertensive rats (SHR) with angiotensin converting enzyme (ACE) inhibitors, calcium channel antagonists, angiotensin receptor antagonists and novel beta blockers such as carvedilol, has been shown to result in regression of the altered structure of small arteries in different vascular beds, in addition to improved endothelium-dependent relaxation. Several studies in hypertensive patients have now shown that treatment with some ACE inhibitors (cilazapril and perindopril) or extended release calcium channel antagonists (nifedipine GITS) induces similar effects in sma...Continue Reading

References

Nov 1, 1992·American Journal of Hypertension·L Y Deng, E L Schiffrin
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Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
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Citations

Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M El MabroukE L Schiffrin
Dec 9, 2003·Physiological Measurement·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Apr 12, 2006·Sleep & Breathing = Schlaf & Atmung·Hans-Werner DuchnaRiccardo A Stoohs
Aug 14, 2009·Journal of Human Hypertension·R HumarE Battegay
Dec 31, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Giulia Dell'OmoRoberto Pedrinelli
Apr 18, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Begoña Quintana-VillamandosMaria Carmen González
Oct 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mehmet KanbayRichard J Johnson

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