Vascular Remodelling Relates to an Elevated Oscillatory Shear Index and Relative Residence Time in Spontaneously Hypertensive Rats

Scientific Reports
Zhiyan ChenWei Gao

Abstract

Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensive-treated SHRs. Twenty-four adult male SHRs and Wistar-Kyoto rats (WKYs) were randomly divided into four groups and treated for 7 days as follows: WKY-CON (WKYs + saline), WKY-NIF (WKYs + nifedipine, 50 mg/kg/day), SHR-CON (SHRs + saline), and SHR-NIF (SHRs + nifedipine). Aortic computational fluid dynamics (CFD) models were simulated to obtain the haemodynamic parameters. We found that in the hypertensive (SHR-CON) and blood pressure-controlled (SHR-NIF) groups, the oscillatory shear index (OSI) and relative residence time (RRT), which are key haemodynamics indices, were markedly elevated. Furthermore, there was a correlation between both the elevated OSI and RRT with the vascular wall thickening in regions near the inner wall of the aortic arch. Our research demonstrates that haemodynamics remains disturbed even if the blood pressure is normalized. In addition, vascular remodelling may play an important role in ...Continue Reading

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Citations

Feb 29, 2020·Journal of Biomechanical Engineering·Min-Hyuk ParkTinghui Zheng
Jul 6, 2020·International Journal for Numerical Methods in Biomedical Engineering·Farshad TajeddiniHossein Afshin
Mar 23, 2021·International Journal for Numerical Methods in Biomedical Engineering·Longzhu HanXiao Liu
Jun 19, 2021·Frontiers in Cardiovascular Medicine·Lauren JohnstonAsimina Kazakidi
Sep 28, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Yun ShiWeiguo Fu

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Methods Mentioned

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Software Mentioned

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HyperMesh
Pro Analyzer
Mimics17
SPSS
Geomagic

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