Vascular response after Zilver PTX stent implantation for superficial femoral artery lesions: serial optical coherence tomography findings at 6 and 12 months

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
Yusuke TomoiMasakiyo Nobuyoshi

Abstract

To compare the vascular response after paclitaxel-coated nitinol drug-eluting stent (Zilver PTX) implantation for superficial femoral artery lesions after 6 and 12 months using optical coherence tomography (OCT). Serial OCT examinations were performed in 5 patients (4 men; mean age 78.4 ± 6.8 years) with 9 Zilver PTX stents at 6- and 12-month follow-up. Variables evaluated included neointimal thickness and apposition on each strut, the incidence of extrastent lumen (ESL), peristrut low-intensity area (PLIA), and neovascularization at 1-mm intervals. A total of 249 matched cross-section images were evaluated and included 4788 and 4826 struts at 6 and 12 months, respectively. Mean neointimal thickness significantly increased from 480 to 540 µm between 6 and 12 months (p < 0.001). The percentage of uncovered struts tended to decrease at 12 months (3% vs. 2.3%, p = 0.054), whereas the percentage of malapposed struts were similar at both examinations (0.2% vs. 0.2%, p > 0.99). Although the incidence of ESL in cross sections was not different (35% vs. 31%, p = 0.29), median ESL area significantly increased from 6 to 12 months [0.12 (0.04-0.36) vs. 0.31 (0.14-0.59) mm(2), p = 0.003)]. The presence of PLIA (29% vs. 44%, p < 0.001) and ...Continue Reading

References

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Citations

Aug 16, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Kojiro MikiMasaharu Ishihara
Aug 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Dongming HouKeith D Dawkins
May 10, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Shuji OtsukiMónica Masotti
Jul 8, 2016·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Daniel E KendrickVikram S Kashyap
Mar 24, 2016·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Yusuke TomoiKenji Ando
Nov 24, 2017·Cardiovascular Intervention and Therapeutics·Norihiko ShinozakiYuji Ikari
Oct 26, 2018·Circulation. Cardiovascular Interventions·Takashi MiuraUNKNOWN DEBATE in SFA Investigators
Mar 16, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yusuke TomoiKenji Ando

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Methods Mentioned

BETA
ISA

Software Mentioned

OCT
LightLab
JMP

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