Vascular response to biolimus A-9 eluting stent in patients with shorter and prolonged dual antiplatelet therapy: optical coherence tomography sub-study of the NIPPON trial

Heart and Vessels
Koji KurodaNIPPON Investigators

Abstract

Dual antiplatelet therapy (DAPT) with thienopyridine and aspirin is the standard care for the prevention of stent thrombosis. However, the optimal duration and effect of the duration of DAPT on intra-stent thrombus (IS-Th) formation are unknown. The NIPPON study (Nobori Dual Antiplatelet Therapy as Appropriate Duration) was an open label, randomized multicenter, assessor-blinded, trial designed to demonstrate the non-inferiority of shorter (6-month) DAPT to prolonged (18-month) DAPT, after biolimus A9 eluting stent implantation in 3773 patients at 130 sites in Japan. Among them, 101 patients were randomly allocated for an optical coherence tomography (OCT) sub-study to assess the difference of local IS-Th formation between the two groups. In addition to standard OCT parameters, the number of IS-Th formed was counted in each target stent at 8 months. Baseline patient characteristics were not different between the 6- and 18-month groups. IS-Th was detected in 9.8% of the cases and the presence of IS-Th was not significantly different between the two groups (10.9% in 6-month vs. 9.1% in 12-month, P = 0.76). Furthermore, the number of IS-Th formed was not significantly different between the two groups. This OCT sub-study was in lin...Continue Reading

References

Jun 13, 2006·The American Journal of Cardiology·Teruyoshi KumeKiyoshi Yoshida
Mar 23, 2012·Circulation·Marco ValgimigliUNKNOWN Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia Study (PRODIGY) Investigators
May 21, 2013·Journal of the American College of Cardiology·Masahiro NatsuakiUNKNOWN NEXT Investigators
Jun 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Akihide KonishiKen-ichi Hirata
Aug 8, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi KuboUNKNOWN NEXT Investigators
Jan 27, 2015·European Heart Journal·Stefanie Schulz-SchüpkeUNKNOWN Intracoronary Stenting and Antithrombotic Regimen: Safety And EFficacy of 6 Months Dual Antiplatelet Therapy After Drug-Elut
Jun 24, 2017·JACC. Cardiovascular Interventions·Masato NakamuraUNKNOWN NIPPON Investigators

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