PMID: 11327675May 1, 2001Paper

Vascular response to extended wear of hydrogel lenses with high and low oxygen permeability

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Kathy DumbletonD Fonn

Abstract

The purpose of this study was to determine the impact of extended wear of high and low oxygen permeability (Dk) lenses on the development or resolution of limbal hyperemia and corneal neovascularization in a randomized prospective clinical trial. Adapted daily-wear contact lens wearers were randomly assigned to one of two groups. The low-Dk group (N = 23) wore etafilcon A lenses (Dk/t = 40) for up to 7 days and 6 nights, and the high-Dk group (N = 39) wore lotrafilcon A lenses (Dk/t = 175) for up to 30 days and nights. Limbal hyperemia and neovascularization were assessed and graded during 9 months of extended wear. A stratified analysis to determine how change in ocular redness depended on initial presentation was also conducted. On a 0 to 100 scale, extended wear of low-Dk lenses resulted in a 16-point increase in limbal hyperemia (p < 0.0001); no significant change occurred with the high-Dk lenses. The difference was greatest for low-Dk participants who initially presented with lower levels of hyperemia (N = 18). There was a slight resolution of redness in participants who initially presented with higher levels of hyperemia (N = 10) after wearing the high-Dk lenses. Neovascularization increased by an average of 0.5 on a scal...Continue Reading

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Citations

May 30, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Brien A Holden
May 30, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Deborah F SweeneyBrien A Holden
May 30, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Desmond FonnNicola Pritchard
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Dec 25, 2015·ACS Applied Materials & Interfaces·Thierry MoserDrew R Evans
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Apr 15, 2017·Eye & Contact Lens·Yingying ShiJianhua Wang
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Oct 17, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kathryn DumbletonDesmond Fonn
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Dec 26, 2012·Eye & Contact Lens·Kathy DumbletonDesmond Fonn

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