Vascular responses to Angiotensin-(1-7) during the estrous cycle

Endocrine
Liomar A A NevesK B Brosnihan

Abstract

Mesenteric arteries (230-290 microm) were isolated from virgin female rats at diestrous and proestrous phases of the estrous cycle and from ovariectomized (OVX) rats with or without estrogen (E2) replacement (17beta-estradiol, 7.5 + 5 mg pellets, 21 d release). Arteries were mounted in a pressurized myograph system. Angiotensin-(1-7) [Ang-(1-7)] concentration-dependent responses (10(-10)-10(-5) M) were determined in arteries preconstricted with endothelin-1 (10(-7) M). Mesenteric arteries were pretreated with the specific Ang-(1-7) antagonist, D-[Ala7]-Ang-(1-7) (10(-7) M) to assess the Ang-(1-7) receptor-mediated dilator effect. Ang-(1-7) did not dilate mesenteric arteries from virgin rats at diestrus and placebo-treated OVX female rats as compared to the time control; however, Ang-(1-7) elicited a modest dilation at proestrus as compared to diestrus, which reached statistical significance at 10(-8) M concentrations. Ang-(1-7) caused a concentration-dependent vasodilation in mesenteric arteries of females with E2 replacement, with an EC50 of 21 nM. D-[Ala7]-Ang-(1-7) blocked the vasodilator effect of Ang-(1-7). Our results demonstrate that during proestrus Ang-(1-7) elicits modest vasodilation as compared to diestrus, but lack...Continue Reading

Citations

Jun 1, 2012·Canadian Journal of Physiology and Pharmacology·Josette M NorthcottJeffrey T Wigle
Apr 9, 2010·American Journal of Physiology. Renal Physiology·Carlos M Ferrario, Jasmina Varagic
Apr 9, 2005·European Journal of Endocrinology·Dinesh SelvarajahJohn Newell-Price
Jul 27, 2007·Vascular Pharmacology·Kathleen M EysterDouglas S Martin
Jul 9, 2010·Fundamental & Clinical Pharmacology·Kimiaki KomukaiMichihiro Yoshimura
Jul 3, 2019·Biology of Sex Differences·Melissa C WhiteAmy C Arnold
Jan 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Justin L GrobeMichael J Katovich
Feb 23, 2021·European Journal of Pharmacology·Persoulla A Nicolaou
Jul 6, 2021·Frontiers in Cardiovascular Medicine·Lin ZhangHong Sun

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