Abstract
Little is known about the possible role of leukocytes in the pathogenesis of vasospasm. We hypothesized that vasoactive products released by leukocytes might produce constriction of atherosclerotic arteries. To test this hypothesis, we infused fmet-leu-phe (fMLP), a peptide that activates leukocytes to release their vasoactive products, into the perfused hind limb of normal and atherosclerotic cynomolgus monkeys. Infusion of fMLP did not change resistance of large arteries in normal monkeys. In contrast, fMLP produced pronounced constriction of large arteries in atherosclerotic monkeys. To determine whether leukotrienes, platelet-activating factor, or prostaglandin E2 (PGE2), which are released by leukocytes, may contribute to leukocyte-induced vasoconstriction in atherosclerotic monkeys, we injected leukotriene D4, platelet-activating factor, and PGE2 intra-arterially into the perfused hind limb. Leukotriene D4 and platelet-activating factor had minimal effects on large arteries in both normal and atherosclerotic monkeys. PGE2 produced marked constriction of large arteries in atherosclerotic, but not normal, monkeys. Thus, pronounced constriction in atherosclerotic, but not normal, arteries during infusion of fMLP suggests tha...Continue Reading
References
May 1, 1978·European Journal of Pharmacology·G J DustingJ R Vane
Sep 1, 1976·Prostaglandins·P S KulkarniP Needleman
May 1, 1988·Journal of Neurosurgery·T NakagomiJ H Lee
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L JonassonG K Hansson
Jan 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M B Zucker, V T Nachmias
Jun 1, 1987·Inflammation·E J LeonardA Skeel
Jun 1, 1986·Circulation Research·P C FreimanD G Harrison
Oct 1, 1987·British Journal of Pharmacology·E CoëffierB B Vargaftig
Jun 1, 1988·The Journal of Clinical Investigation·H YamamotoP D Henry
Sep 1, 1987·Prostaglandins, Leukotrienes, and Medicine·P HenrikssonU Diczfalusy
Apr 4, 1986·Science·B C BerkR C Webb
Nov 1, 1986·Journal of Biochemistry·M OdaK Saito
Oct 1, 1985·Circulation·P M Vanhoutte, D S Houston
Mar 1, 1985·The Journal of Clinical Investigation·A S EversP Needleman
Jul 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M L ArmstrongD J Piegors
Mar 15, 1972·Nature: New Biology·H Shio, P Ramwell
Nov 30, 1984·Biochemical and Biophysical Research Communications·B DewaldM Baggiolini
Jan 1, 1984·The American Journal of Physiology·R Takemura, Z Werb
Jan 7, 1983·Biochimica Et Biophysica Acta·C E WalshM Waite
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·N A PawlowskiW A Scott
Jul 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A FaggiottoL Harker
Jan 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P H RollandA Serradimigni
Feb 1, 1984·Journal of Pharmacobio-dynamics·Y KasuyaK Shigenobu
Jun 1, 1984·Circulation Research·D D HeistadA L Mark
Jul 1, 1980·The American Journal of Cardiology·R N MacAlpin
Jan 1, 1983·The Journal of Clinical Investigation·M L ArmstrongF M Abboud
Sep 28, 1981·Life Sciences·G KitoK Kikuchi
Jan 1, 1980·Prostaglandins and Medicine·A L GottliebP J Kadowitz
Dec 1, 1981·Prostaglandins and Medicine·D AharonyA M Lefer
Aug 1, 1980·The Journal of Clinical Investigation·P D Henry, M Yokoyama
Citations
Aug 1, 1992·Atherosclerosis·A MüggeJ A Lopez
Jul 5, 1996·International Journal of Cardiology·Y AbeY Maruyama
Aug 1, 1992·Journal of the American College of Cardiology·J K WilliamsT B Clarkson
Mar 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A Chinellato, E Ragazzi
May 29, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haim TapieroKenneth D Tew
Jan 1, 1997·Progress in Cardiovascular Diseases·G R De Meyer, A G Herman
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C R WhiteB A Freeman
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R HärtlG J del Zoppo
Feb 11, 1995·Lancet·G K GoodeA M Heagerty
Jul 17, 2008·Archives of Physiology and Biochemistry·Miguel A IñiguezManuel Fresno
Aug 6, 2010·Atherosclerosis·Jae-Hoon ChoiGoo Taeg Oh
Jul 11, 1992·Progress in Cardiovascular Diseases·A P SelwynP Ganz
May 1, 1992·Progress in Cardiovascular Diseases·J FareedR Pifarre
Dec 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·M R AdamsM J Jayo
Dec 14, 2006·Prostaglandins & Other Lipid Mediators·Kristina M FetalveroJohn Hwa
Mar 1, 1992·Atherosclerosis·R CirilloM Prosdocimi
Jul 1, 1993·European Journal of Clinical Investigation·S MoncadaA Higgs
Nov 1, 1994·Stroke; a Journal of Cerebral Circulation·S E AkopovJ Seylaz
Jun 1, 1991·Stroke; a Journal of Cerebral Circulation·F M FaraciD D Heistad
Mar 1, 1991·Hypertension·A Mügge, J A Lopez
Apr 18, 1994·Annals of the New York Academy of Sciences·S KaulD D Heistad
Jan 1, 1991·Annals of Medicine·A MüggeP R Lichtlen
May 1, 1996·Pflügers Archiv : European journal of physiology·M SetoY Sasaki
Jul 25, 2017·Experimental Physiology·Shinichi AsanoPaul D Chantler
Feb 24, 2001·Journal of Hypertension·K Ando, T Fujita
Jan 1, 1996·Heart and Vessels·A SakaiK Kodama
Mar 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·A S LübbeP D Harris
Mar 10, 2001·The Journal of Nutrition·K SlowingT Tejerina