PMID: 1208545Nov 1, 1975Paper

Vascular responses to plasma hypoosmolality in man

Proceedings of the Society for Experimental Biology and Medicine
H W Overbeck, M B Pamnani

Abstract

To study limb vascular responses to plasma hypoosmolality in man, we infused test solutions of hypoosmolar NaCl (145 mOsm/kg) and control solutions of isosmolar NaCl (290 mOsm/kg) into the brachial arteries of 14 mornotensive and 13 essential hypertensive patients. Limb blood pressures were monitored, limb blood flow was measured by indicator-dilution, and limb vascular resistance was calculated as mmHg/ml flow/min/100 cm3 limb volume. The infusions did not significantly change systemic plasma osmolality, sodium concentration, or blood pressure. Compared to control infusions, the hypoosmolar infusions decreased limb venous plasma osmolality and serum sodium concentrations by an average of 12 mOsm/kg and 7 mEq/1, respectively. Compared to control infusions, limb venous serum concentrations of potassium, calcium, magnesium, or blood hematocrit were not altered by the hypoosmolar infusions. In response to the hypoosmolar infusions, limb resistance increased by 28% in normotensives and by 26% in hypertensives. We conclude that the acute local vascular response to a small reduction in plasma osmolality in the limb of man is a large increase in vascular resistance. We found no evidence for abnormal responses to plasma hypoosmolality ...Continue Reading

Citations

May 15, 1979·Pflügers Archiv : European journal of physiology·R Gallego, C Belmonte
Jan 1, 1979·Clinical and Experimental Hypertension : CHE·H W Overbeck
Sep 1, 1978·Microvascular Research·P M Vanhoutte, W J Janssens
Feb 11, 2015·Microvascular Research·Walter H ReinhartSergey S Shevkoplyas
Apr 28, 2006·Journal of the Society for Gynecologic Investigation·Atsushi KomatsuYuji Taketani
Sep 1, 1982·Hypertension·M S Paller, S L Linas

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