PMID: 8960703Nov 1, 1996Paper

Vascular responses to stimulation of carotid, aortic and coronary artery baroreceptors with pulsatile and non-pulsatile pressures in anaesthetized dogs

Experimental Physiology
N C McMahonR Hainsworth

Abstract

This research was designed to compare coronary, carotid and aortic arch baroreceptors in terms of the ranges of pressures required to elicit reflex vascular responses and the possible differences between the responses to pulsatile and non-pulsatile stimuli. Dogs were anaesthetized with alpha-chloralose, artificially ventilated and the chests opened wide. A perfusion circuit allowed independent control of pressures distending the three baroreceptor regions. A cardiopulmonary bypass and ventricular fibrillation prevented cardiac pulsations from influencing coronary baroreceptor pressure. The caudal region of the animal was perfused at constant flow and vascular resistance responses were assessed from changes in perfusion pressure. Only tests in which the overall response exceeded 3 kPa (22.5 mmHg) were analyzed. Reflex responses were obtained to significantly lower coronary pressures than were required to induce responses from other regions. The inflexion points of the stimulus-response curves for pulsatile coronary, carotid and aortic pressures were 10.5 +/- 0.6, 15.5 +/- 1.8 and 16.4 +/- 1.7 kPa (79 +/- 5, 116 +/- 14 and 123 +/- 13 mmHg, respectively; values are means +/- S.E.M.). When the responses to pulsatile stimuli were co...Continue Reading

Citations

Sep 24, 2013·Experimental Physiology·Roger Hainsworth
Feb 23, 2011·Journal of Pharmacological and Toxicological Methods·L J Shiry, R L Hamlin
Nov 10, 1998·The Journal of Physiology·N C McMahonR Hainsworth
Aug 5, 2010·Critical Care Medicine·Christopher W MastropietroAshok P Sarnaik
Dec 22, 1998·Biomedizinische Technik. Biomedical Engineering·S SchulzU Kiencke
Jun 22, 2011·The Journal of Physiology·Jonathan P MooreMark J Drinkhill

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