PMID: 2497651May 1, 1989Paper

Vascular responsiveness in adrenalectomized rats with corticosterone replacement

The American Journal of Physiology
D N DarlingtonM F Dallman

Abstract

To determine under resting, unstressed conditions the circulating glucocorticoid concentrations that best maintain sensitivity of the vascular smooth muscle and baroreceptor responses to vasoactive agents, rats with vascular cannulas were sham-adrenalectomized (sham) or adrenalectomized (ADRX) and provided with four levels of corticosterone replacement (approximately 100 mg fused pellets of corticosterone: cholesterol 0, 20, 40, and 80% implanted subcutaneously at the time of adrenal surgery). Changes in vascular and baroreflex responses were determined after intravenous injection of varying doses of phenylephrine and nitroglycerin with measurement of arterial blood pressure and heart rate in the conscious, chronically cannulated rats. Vascular sensitivity was decreased, and resting arterial blood pressure tended to be decreased in the adrenalectomized rats; both were restored to normal with levels of corticosterone (40%), which also maintained body weight gain, thymus weight, and plasma corticosteroid binding globulin concentrations at normal values. The baroreflex curve generated from the sham group was different from the curves generated from the ADRX+0, 20, and 40% groups, but not different from that of the ADRX+80% group, ...Continue Reading

Citations

Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Daliao XiaoLubo Zhang
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D A Scheuer, A G Bechtold
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D A Scheuer, S W Mifflin
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Keller-Wood, C E Wood
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deborah A Scheuer, Andrea G Bechtold

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