Vascular Risk Reduction in Obesity through Reduced Granulocyte Burden and Improved Angiogenic Monocyte Content following Bariatric Surgery

Cell Reports Medicine
David A HessSubodh Verma

Abstract

Bariatric surgery, in addition to the benefit of sustained weight loss, can also reduce cardiometabolic risk and mortality. Lifelong vessel maintenance is integral to the prevention of cardiovascular disease. Using aldehyde dehydrogenase activity, an intracellular detoxifying enzyme present at high levels within pro-vascular progenitor cells, we observed an association between chronic obesity and "regenerative cell exhaustion" (RCE), a pathology whereby chronic assault on circulating regenerative cell types can result in adverse inflammation and diminished vessel repair. We also describe that, at 3 months following bariatric surgery, systemic inflammatory burden was reduced and pro-angiogenic macrophage precursor content was improved in subjects with severe obesity, suggesting the restoration of a microenvironment to support vessel homeostasis. These data suggest that bariatric surgery may reverse deleterious events that predispose patients with morbid obesity to cardiovascular risk.

References

Apr 24, 2008·The Journal of Clinical Endocrinology and Metabolism·Blandine LaferrèreBlanca Olivan
Jan 14, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marlies NoordzijKitty J Jager
Jul 30, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Christine PoitouIsabelle Cremer
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Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
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Methods Mentioned

BETA
flow cytometry
gastric bypass
density gradient centrifugation

Clinical Trials Mentioned

NCT04132531

Software Mentioned

FlowJo
GraphPad Prism

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