Vascular smooth muscle and nitric oxide synthase

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Igor B BuchwalowMarkus M Lerch

Abstract

The concept of endothelium-derived relaxing factor (EDRF) put forward in 1980 by Furchgott and Zawadzki implies that nitric oxide (NO) produced by NO synthase (NOS) in the endothelium diffuses to the underlying vascular smooth muscle, where it modulates vascular tone as well as vascular smooth muscle cell (VSMC) proliferation by increasing cGMP formation with subsequent activation of cGMP-dependent protein kinase. According to this concept, VSMC do not express NOS by themselves. This attractive, simple scheme is now under considerable debate. To address this issue, we designed this study with the use of a novel supersensitive immunocytochemical technique of signal amplification with tyramide and electron microscopic immunogold labeling complemented with Western blotting, as in our recent studies demonstrating NOS in the myocardial and skeletal muscles. We provide the first evidence that, in contrast to the currently accepted view, VSMC in various blood vessels express all three NOS isoforms depending on the blood vessel type. These findings suggest an alternative mechanism by which local NOS expression may modulate vascular functions in an endothelium-independent manner.

References

Oct 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C Adams
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D J StuehrC F Nathan
Dec 20, 1989·Journal of Immunological Methods·M N BobrowG J Litt
Nov 1, 1987·British Journal of Pharmacology·K ShikanoB A Berkowitz
Jul 1, 1980·The Histochemical Journal·K T Tokuyasu
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·B GastonJ S Stamler
Dec 8, 1994·Nature·L KobzikJ S Stamler
Jun 15, 1995·Biochemical and Biophysical Research Communications·L KobzikJ S Stamler
Nov 1, 1994·The Journal of Clinical Investigation·R H SteinhornJ A Russell
Jan 1, 1993·Life Sciences·M ZehetgruberR J Bing
Nov 1, 1996·Journal of Molecular and Cellular Cardiology·L CominiR Ferrari
Dec 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I GathU Förstermann
Nov 14, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R von WasielewskiA Georgii
Nov 20, 1997·The Journal of Clinical Investigation·C Nathan
Jun 20, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A H HopmanE J Speel
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·I Fleming, R Busse
Jun 9, 1999·The Biochemical Journal·I GathU Förstermann
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·P M SchwarzU Förstermann
Dec 22, 1999·Zentralblatt für Veterinärmedizin. Reihe A·S PesićM Radenković
Feb 24, 2000·The Journal of Pathology·H Li, U Förstermann
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C M BrophyJ S Pollock
Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·A M KahnS Zhang
Jul 18, 2000·American Journal of Physiology. Cell Physiology·L SandirasegaraneM Kester
Sep 16, 2000·European Journal of Pharmacology·M WaliaA K Grover
Mar 28, 2001·Molecular and Cellular Biochemistry·I B BuchwalowH Haller
Apr 9, 2001·Nitric Oxide : Biology and Chemistry·C Napoli, L J Ignarro
Apr 28, 2001·Journal of Pharmacological and Toxicological Methods·H Ding, C R Triggle
Jun 22, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S K OzelA O Aktan

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Citations

May 24, 2006·Acta Neuropathologica·Igor B BuchwalowWerner Boecker
Nov 18, 2005·Histochemistry and Cell Biology·Karla PunktIgor B Buchwalow
Feb 25, 2010·Pflügers Archiv : European journal of physiology·Hiroaki Shimokawa, Masato Tsutsui
Oct 26, 2012·Cell Biochemistry and Biophysics·Hongyan KangXiaoyan Deng
Aug 5, 2003·Nitric Oxide : Biology and Chemistry·Kathryn Lamping, Frank Faraci
Mar 11, 2004·Journal of Asian Natural Products Research·Yu-Juan Li, Guan-Hua Du
Mar 18, 2004·Antioxidants & Redox Signaling·Jan SlezakHermann Haller
May 14, 2005·Antioxidants & Redox Signaling·Yavuz Cakir, Scott W Ballinger
Feb 4, 2009·Antioxidants & Redox Signaling·Konstantin G Birukov
Dec 13, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Donald T Stuss
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter J KuhlencordtGeorg Ertl
Apr 23, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Li LiDavid G Harrison
Aug 2, 2011·Biological & Pharmaceutical Bulletin·Maria Grazia CerritoMarialuisa Lavitrano
May 12, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato TsutsuiNobuyuki Yanagihara
Aug 22, 2013·World Journal of Gastroenterology : WJG·Erwin Biecker
Jun 19, 2013·Journal of UOEH·Kiyoko ShibataMasato Tsutsui
Dec 4, 2013·Antioxidants & Redox Signaling·Jennifer K BendallMark J Crabtree
Jun 19, 2013·Chinese Journal of Integrative Medicine·Yan-ju LiAn-sheng Sun
Dec 14, 2011·International Journal of Hypertension·Claudio Joo TuroniMaría Peral de Bruno
Dec 17, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·John A DonaldMelissa S Cameron
Jun 3, 2009·Cellular and Molecular Life Sciences : CMLS·Jürgen SchnekenburgerMarkus M Lerch
Aug 6, 2009·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Olga Pechanova, Fedor Simko
Aug 2, 2007·Journal of Cardiovascular Pharmacology·Viktoriya P EkshyyanTammy R Dugas
Jan 8, 2011·Clinical and Experimental Hypertension : CHE·Claudio Joo TuroniMaría Peral de Bruno
Apr 3, 2010·Archives of Oral Biology·Jelena RoganovićDragica Stojić
May 6, 2008·The Journal of Surgical Research·Jens Peter HölzenHans-Ullrich Spiegel
Feb 23, 2007·Acta histochemica·K PunktI B Buchwalow
Oct 25, 2006·The Journal of Thoracic and Cardiovascular Surgery·George D WebbPhilip K Moore
May 29, 2013·Scientific Reports·Igor BuchwalowWerner Boecker
Mar 14, 2007·Journal of Cellular Physiology·Federica CoralliniGiorgio Zauli

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