Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling.

Cardiovascular Research
Joshua M SpinPhilip S Tsao

Abstract

Differentiated vascular smooth muscle cells (SMCs) retain the capacity to modify their phenotype in response to inflammation or injury. This phenotypic switching is a crucial component of vascular disease, and is partly dependent on epigenetic regulation. An appreciation has been building in the literature for the essential role chromatin remodelling plays both in SMC lineage determination and in influencing changes in SMC behaviour and state. This process includes numerous chromatin regulatory elements and pathways such as histone acetyltransferases, deacetylases, and methyltransferases and other factors that act at SMC-specific marker sites to silence or permit access to the cellular transcriptional machinery and on other key regulatory elements such as myocardin and Kruppel-like factor 4 (KLF4). Various stimuli known to alter the SMC phenotype, such as transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), oxidized phospholipids, and retinoic acid, appear to act in part through effects upon SMC chromatin structure. In recent years, specific covalent histone modifications that appear to establish SMC determinacy have been identified, while others alter the differentiation state. In this article, we re...Continue Reading

References

Jan 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E M Bradbury
Jul 1, 1995·Physiological Reviews·G K Owens
Sep 5, 1996·Nature·D ChakravartiR M Evans
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·S MinucciK Ozato
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jan 16, 1999·Nucleic Acids Research·A P Wolffe, J J Hayes
Jan 19, 2000·Nature·B D Strahl, C D Allis
Mar 1, 2000·Trends in Biochemical Sciences·L Aravind, E V Koonin
Nov 1, 2000·Cell·P CheungP Sassone-Corsi
Nov 14, 2000·Molecular and Cellular Biology·C PoizatL Kedes
Mar 30, 2001·The Journal of Biological Chemistry·N Vo, R H Goodman
Jun 5, 2001·Nature Reviews. Molecular Cell Biology·R Marmorstein
Sep 5, 2001·Current Opinion in Genetics & Development·T A McKinseyE N Olson
Dec 1, 2001·The EMBO Journal·A PolesskayaA Harel-Bellan
Jun 1, 2002·The Journal of Biological Chemistry·Chao QiYi-Jun Zhu
Oct 24, 2002·Journal of Molecular and Cellular Cardiology·Jiyuan ChenJoseph M Miano
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Da-Zhi WangEric N Olson
Dec 11, 2002·Current Opinion in Cell Biology·Timothy A McKinseyEric N Olson
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Qi Jun ZhangMartin Bennett
Mar 21, 2003·Biochemical and Biophysical Research Communications·Eric C DietzeVictoria L Seewaldt
Mar 22, 2003·Current Opinion in Cell Biology·Wolfgang FischleC David Allis
May 2, 2003·Annals of the New York Academy of Sciences·Sam ThiagalingamJose F Ponte
May 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhigao WangEric N Olson
Jul 31, 2003·Molecular Cell·Marcella FulcoVittorio Sartorelli
May 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·V G ALLFREYA E MIRSKY
Jan 28, 2004·Cell·Sepideh Khorasanizadeh
Mar 3, 2004·Molecular and Cellular Biology·Jonathan E DodgeEn Li
Jul 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Tadashi YoshidaGary K Owens
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Aug 18, 2004·Biochemical Pharmacology·Eric Kalkhoven

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Citations

Feb 21, 2013·Current Atherosclerosis Reports·Hannes M FindeisenDennis Bruemmer
Jun 17, 2014·Canadian Journal of Physiology and Pharmacology·Swastika SurDevendra K Agrawal
Mar 6, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhang Hai, Wang Zuo
Jan 7, 2015·The Biochemical Journal·Biraja C DashYibing Qyang
May 3, 2013·Clinical Science·Karen E Porter, Kirsten Riches
Jul 9, 2016·Nature Communications·Clint L MillerThomas Quertermous
Sep 29, 2017·Physiological Reviews·Patrick LacolleyStéphane Laurent
Dec 19, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Lars MaegdefesselNicholas J Leeper
Jan 1, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrés I RodríguezPatrick J Pagano
Oct 10, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Delphine GomezGary K Owens
Jul 3, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Delphine GomezJean-Baptiste Michel
May 12, 2016·American Journal of Physiology. Endocrinology and Metabolism·Aliya GiffordE Brian Welch
May 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Samira Tabaei, Seyyedeh Samaneh Tabaee
Feb 15, 2020·International Journal of Molecular Sciences·Verónica Guarner-LansIsrael Pérez-Torres
Apr 9, 2015·Journal of Cardiovascular Pharmacology·Olayemi O AdeoyeWilliam J Pearce
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Francesca Bartoli-LeonardRia Weston
Apr 12, 2019·Scientific Reports·Geon JeongYoung-Kook Kim
May 11, 2020·Life Sciences·Armita Mahdavi GorabiAmirhossein Sahebkar
Sep 3, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Carmen YapVivian de Waard
Nov 20, 2021·Journal of the American Heart Association·Haocheng LuYanbo Fan

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