Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats

Hypertension
P Y ChenP W Sanders

Abstract

Salt-sensitive hypertension in the Dahl/Rapp rat (S strain) is prevented by L-arginine. Based on the observations that dexamethasone prevented the antihypertensive effect of L-arginine in these animals and the suggestion that a locus in or near an inducible nitric oxide synthase (NOS) gene on chromosome 10 cosegregated with hypertension in some F2 crosses that utilized the S rat, the present study explored the hypothesis that the vascular smooth muscle isoform of inducible NOS (NOS2) was abnormal in S rats. Primary cultures of aortic smooth muscle cells from S rats demonstrated impaired inducible NO production, which improved with increased L-arginine in the medium. Sequence analysis identified a single T-->C transversion that produced an amino acid substitution (S714P) between the FAD and FMN binding sites and a restriction fragment length polymorphism. This restriction fragment length polymorphism was present only in S rats. The mutation of NOS2 and the role of this enzyme in the pathogenesis of salt-sensitive hypertension in the Dahl/Rapp rat require further investigation.

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Citations

May 1, 2009·Journal of Human Hypertension·Y Al-SolaimanB M Egan
May 29, 2009·American Journal of Physiology. Renal Physiology·Anees Ahmad Banday, Mustafa F Lokhandwala
Mar 7, 2001·Kidney International·P W SandersJ A Thompson
Oct 4, 2015·International Journal of Biological Macromolecules·Liming LinXiaoming Wei
Nov 24, 2004·European Journal of Heart Failure·Michael D SosinGregory Y H Lip
Jul 31, 1998·Molecular Genetics and Metabolism·P A WoodP W Sanders
Nov 8, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·P Poredos
Apr 14, 2005·American Journal of Physiology. Renal Physiology·Wei-Zhong Ying, Paul W Sanders
Dec 8, 2006·Journal of the American Society of Nephrology : JASN·Wei-Zhong YingPaul W Sanders
Feb 7, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pablo A Ortiz, Jeffrey L Garvin
Sep 12, 2000·American Journal of Hypertension·L X CubedduR M Baldonedo
Jul 17, 2003·American Journal of Physiology. Renal Physiology·Wei-Zhong Ying, Paul W Sanders
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mátyás SzentiványiAllen W Cowley
Oct 12, 1999·The American Journal of Physiology·W Z Ying, P W Sanders
Aug 1, 2012·Physiological Research·J ZichaJ Kuneš
Oct 10, 1998·Science·C Lenfant

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