Vascular strategies for enhancing tumour response to radiation therapy

Technology in Cancer Research & Treatment
Ahmed El KaffasGregory J Czarnota

Abstract

Radiation therapy is prescribed to more than 50% of patients diagnosed with cancer. Although mechanisms of interaction between radiation and tumour cells are well understood on a molecular level, much remains uncertain concerning the interaction of radiation with the tumour as a whole. Recent studies have demonstrated that single large doses of radiation (8-20 Gy) may primarily target tumour endothelial cells, leading to secondary tumour clonogenic cell death. These studies suggest that blood vessels play an important role in radiation response. As a result, various strategies have been proposed to effectively combine radiation with vascular targeting agents. While most proposed schemes focus on methods to disrupt tumour blood vessels, recent evidence supporting that some anti-angiogenic agents may "normalize" tumour blood vessels, in turn enhancing tumour oxygenation and radiosensitivity, indicates that there may be more efficient strategies. Furthermore, vascular targeting agents have recently been demonstrated to enhance radiation therapy by targeting endothelial cells. When combined with radiation, these agents are believed to cause even more localized vascular destruction followed by tumour clonogenic cell death. Taken tog...Continue Reading

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Citations

Nov 13, 2013·Microvascular Research·Ahmed El KaffasGregory J Czarnota
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Gregory J CzarnotaAnoja Giles
May 21, 2016·Cancer Gene Therapy·M StimacG Sersa
Mar 26, 2015·Future Oncology·Ahmed El Kaffas, Gregory J Czarnota
Mar 6, 2018·Journal of the National Cancer Institute·Ahmed El KaffasGregory J Czarnota
Mar 6, 2015·Biological Chemistry·Gregory J Czarnota
Jul 5, 2018·Technology in Cancer Research & Treatment·Monika SavarinGregor Sersa
Dec 23, 2020·Journal of the National Cancer Institute·Salma K JabbourMansoor M Ahmed

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